Ingrid Dijkgraaf

Associate professor

Dr Ingrid Dijkgraaf has graduated with specialisation in Organic Chemistry at Wageningen University. Subsequently, she has worked on synthesis and biologic evaluation of alpha-v-beta-3-binding peptides and peptidomimetics at the Department of Medicinal Chemistry and Chemical Biology at Utrecht University, and at the Department of Nuclear Medicine at the Radboud University Nijmegen. After obtaining her PhD, she worked as post-doc at the Technical University of Munich, the Radboud University of Nijmegen and The Scripps Research Institute.

Since 2011, she has been working at Maastricht University. Focus of her research is design and synthesis of peptides and proteins using Solid-Phase Peptide Synthesis and Native Chemical Ligation. These compounds are conjugated with chelators, fluorescent labels, and multimodality tags allowing molecular imaging of cardiovascular diseases and cancer. Synthesised compounds are evaluated in in vitro and in vivo studies.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.350

  • 2026
    • Nandy, M., Ghosh, U., Ganar, K. A., Ippel, H., Dijkgraaf, I., & Deshpande, S. (2026). pH-Tunable Material Properties of Glycine-Rich Condensates from Tick Bioadhesive. Advanced Functional Materials, 36(10), Article e15418. https://doi.org/10.1002/adfm.202515418
  • 2025
    • Xin, X., Dijkgraaf, I., Hackeng, T. M., & Koenen, R. R. (2025). Generation and characterization of platelet-derived extracellular vesicle analogues from lyophilized platelets. Extracellular Vesicle, 6, Article 100095. https://doi.org/10.1016/j.vesic.2025.100095
    • Park, J., Pho, T., Denisov, S. S., Dijkgraaf, I., & Champion, J. A. (2025). Evasin and TSLPI Tick Salivary Antigen Subunit Vaccine Nanoparticles Induce Humoral and Cellular Immunity. ACS Nanoscience Au, 5(5), 337-343. https://doi.org/10.1021/acsnanoscienceau.5c00034
    • Denisov, S. S., Bialek, E. L., Beretta, F., Smagurauskaite, G., Ippel, H., Fijlstra, E., Kale, S. S., Timmerman, P., Hackeng, T. M., Proost, P., Goldflam, M., & Dijkgraaf, I. (2025). Chemokine-Binding All-D-CLIPS Peptides Identified Using Mirror-Image Phage Display. ACS Chemical Biology, 20(11), 2798-2807. https://doi.org/10.1021/acschembio.5c00726
    • Cong, Y., Biemans, R., Lieuwes, N. G., Suijlen, D., Lambin, P., Dijkgraaf, I., Bauwens, M., Yaromina, A., & Dubois, L. J. (2025). Development of a novel anti-CEACAM5 VHH for SPECT imaging and potential cancer therapy applications. European Journal of Nuclear Medicine and Molecular Imaging, 52(12), 4569-4581. https://doi.org/10.1007/s00259-025-07321-z
    • Zhao, Y., Hadavi, D., Scurti, E., Viitala, T., Dijkgraaf, I., & Honing, M. (2025). Cell-based surface plasmon resonance approach for monitoring the inhibitory effect of Evasin-3 on Interleukin-8. Analytica Chimica Acta, 1359, Article 344091. https://doi.org/10.1016/j.aca.2025.344091
    • Ganar, K. A., Nandy, M., Turbina, P., Chen, C., Suylen, D., Nihoul, E., Pascoe, E. L., van der Beelen, S., Plaum, M., van den Bos, L., Koenraadt, C. J. M., Dijkgraaf, I., & Deshpande, S. (2025). Phase separation and ageing of glycine-rich protein from tick adhesive. Nature Chemistry, 17(2), 186-197. Article 490. https://doi.org/10.1038/s41557-024-01686-8
  • 2024
    • Chai, J., Wu, J., Yang, J., Ye, T., Gao, Y., Zeng, B., Xiong, W., Kotsyfakis, M., Dijkgraaf, I., Liu, J., Chen, X., & Xu, X. (2024). Cath-HG improves the survival rates and symptoms in LPS-induced septic mice due to its multifunctional properties. International Immunopharmacology, 143(Pt 1), Article 113332. https://doi.org/10.1016/j.intimp.2024.113332
    • Gentier, A., Aizaz, M., Halder, M., Florea, A., Dijkgraaf, I., Mottaghy, F. M., Hackeng, T., & Kooi, M. E. (2024). Why Current Detection of Vascular Calcification Falls Short and How to Improve on It. TH open : companion journal to thrombosis and haemostasis, 08(04), e340-e349. https://doi.org/10.1055/a-2495-1444
    • Xiong, W., Chai, J., Wu, J., Li, J., Lu, W., Tian, M., Jmel, M. A., Ippel, J. H., Kotsyfakis, M., Dijkgraaf, I., Liu, S., & Xu, X. (2024). Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation. Research (Washington, D.C.), 7, Article 0381. https://doi.org/10.34133/research.0381