Kanin Wichapong

Post doc

Dr Kanin Wichapong received his PhD degree in chemistry from Chulalongkorn University, Bangkok, Thailand. After completion of his PhD, he went back and worked as a postdoctoral researcher at Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany where he also carried out parts of his PhD. During his PhD and post-doc period, he worked on computational and physical chemistry subjects by applying in silico drug discovery and design technologies (e.g. virtual screening and molecular docking) to identify and develop novel inhibitors against different target proteins.

To broaden his research horizons with respect to new research fields in a new science environment, in December 2012 he moved to work at the Department of Biochemistry, Maastricht University. His main research focusses on applications of in silico approaches (such as molecular docking, molecular dynamics simulations, and binding free energy calculation) to study and investigate protein-protein interactions as well as to identify and design novel compounds (small compounds or peptides) to modulate protein-protein interactions. The identified bioactive compounds can be further developed as drugs to treat for several related diseases (e.g. cardiovascular diseases and cancer).

 

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.301

  • 2025
    • Aroca-Crevillen, A., Martin-Salamanca, S., Torres, L. S., Crainiciuc, G., Sicilia, J., Penaloza-Martinez, E., Rosillo, N., Molina-Moreno, M., Adrover, J. M., Rubio-Ponce, A., Vicanolo, T., Liu, X., Wichapong, K., Nunez, V., Balabanian, K., Bachelerie, F., Sancho, D., Casanova-Acebes, M., Ortiz-Perez, J. T., ... Hidalgo, A. (2025). A circadian checkpoint relocates neutrophils to minimize injury. Journal of Experimental Medicine, 223(2), Article e20250240. https://doi.org/10.1084/jem.20250240
    • Huckriede, J., Keulen, G. M., van de Poll, M. C. G., Wichapong, K., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2025). Proteolytic neutralization of extracellular histones by neutrophil elastase is enhanced by heparin. Journal of Thrombosis and Haemostasis, 23(8), 2483-2493. https://doi.org/10.1016/j.jtha.2025.03.039
    • Beukenhorst, A. L., Rice, K. L., Frallicciardi, J., Koldijk, M. H., Boudreau, C. M., Crawford, J., Cornelissen, L. A. H. M., da Costa, K. A. S., de Jong, B. A., Fischinger, S., Julg, B., Klap, J. M., Koch, C. M., Magyarics, Z., Mohamed, F. A. N., Okonkwo, V., Adams, L., McCarthy, C. M., Ronsard, L., ... Goudsmit, J. (2025). Intranasal administration of a panreactive influenza antibody reveals Fc-independent mode of protection. Scientific Reports, 15(1), Article 10309. https://doi.org/10.1038/s41598-025-94314-5
    • Mozaffari, S., Moen, A., Ng, C. Y., Nicolaes, G. A. F., & Wichapong, K. (2025). Structural bioinformatics for rational drug design. Research and practice in thrombosis and haemostasis, 9(1), Article e102691. https://doi.org/10.1016/j.rpth.2025.102691
  • 2024
    • Monard, A., Castoldi, E., De Simone, I., Wichapong, K., van Duijl, T., van den Biggelaar, M., Spada, S., van Doorn, W., Hellenbrand, D., van der Meijden, P., Swieringa, F., Stork, A., ten Cate, H., Beckers, E., Heubel-Moenen, F., & Henskens, Y. (2024). Case Report: Laboratory detection of a thrombotic tendency in a family with hypodysfibrinogenemia and a novel FGG mutation. Frontiers in Cardiovascular Medicine, 11, Article 1488602. https://doi.org/10.3389/fcvm.2024.1488602
    • Keulen, G. M., Huckriede, J., Wichapong, K., & Nicolaes, G. A. F. (2024). Histon activities in the extracellular environment: regulation and prothrombotic implications. Current Opinion in Hematology, 31(5), 230-237. https://doi.org/10.1097/MOH.0000000000000827
    • Singh, A., Kraaijeveld, A. O., Curaj, A., Wichapong, K., Hammerich, L., de Jager, S. C. A., Bot, I., Atamas, S. P., van Berkel, T. J. C., Jukema, J. W., Comerford, I., Mccoll, S. R., Mees, B., Heemskerk, J. W. M., Nicolaes, G. A. F., Hackeng, T., Liehn, E. A., Tacke, F., & Biessen, E. A. L. (2024). CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization. Frontiers in Immunology, 15, Article 1327051. https://doi.org/10.3389/fimmu.2024.1327051
    • Guerkan, B., Poelman, H., Pereverzeva, L., Kruijswijk, D., de Vos, A. F., Groenen, A. G., Nollet, E. E., Wichapong, K., Lutgens, E., van der Poll, T., Du, J., Wiersinga, W. J., Nicolaes, G. A. F., & van 't Veer, C. (2024). The IRAK-M death domain: a tale of three surfaces. Frontiers in Molecular Biosciences, 10, Article 1265455. https://doi.org/10.3389/fmolb.2023.1265455
  • 2023
    • Huckriede, J. B., Beurskens, D. M. H., Wildhagen, K. C. C. A., Reutelingsperger, C. P. M., Wichapong, K., & Nicolaes, G. A. F. (2023). Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3. Journal of Thrombosis and Haemostasis, 21(12), 3557-3567. https://doi.org/10.1016/j.jtha.2023.08.023
    • Thomassen, M. C. L. G. D., Bouwens, B. R. C., Wichapong, K., Suylen, D. P., Bouwman, F. G., Hackeng, T. M., & Koenen, R. R. (2023). Protein arginine deiminase 4 inactivates tissue factor pathway inhibitor-alpha by enzymatic modification of functional arginine residues. Journal of Thrombosis and Haemostasis, 21(5), 1214-1226. https://doi.org/10.1016/j.jtha.2023.01.017