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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Blanche Schroen

Professor

Between 2002 and 2006, Blanche Schroen completed her PhD at Maastricht University’s CARIM School for Cardiovascular Diseases, Department of Cardiology with Professors Yigal Pinto, Harry Crijns and Stephane Heymans. The research focused on uncovering molecular and genetic factors that increase heart failure risk using ‘omics techniques. She then continued as a postdoctoral fellow in cardiac genomics at Imperial College London in the lab of Professors Timothy Aitman and Stuart Cook, supported by an NWO Rubicon grant.

In 2008, she returned to Maastricht University to study non-coding RNAs as risk factors for heart failure. Several personal grants, including NWO Veni and Vidi and NHS Dekker awards, enabled her to expand her research into cardiac genomics and the underlying mechanisms of heart failure. Her group’s work on cardiac inflammatory microRNAs helped show that immune activation plays an early role in heart failure and may be a promising therapeutic target.

Her main expertise includes the genetics and molecular biology of non-coding RNAs related to heart failure, with a focus on fibrosis, cardiomyocyte hypertrophy and metabolism, inflammation and immune cell roles, and vascular and platelet functions.

Schroen’s group is now based in the Department of Physiology at CARIM. In addition to leading her research group, she chairs the faculty’s Science Committee, holds several educational coordinator roles, and actively collaborates through consortium grants that support team science.

Blanche-schroen

Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2025
    • D'Italia, G., Coenen, D. M., Lemmens, T. P., Brandts, L., Wielders, S. J. H., Nagy, M., Mourmans, S. G. J., Achten, A., Al-Abadi, A., Weerts, J., Aizpurua, A. B., van Empel, V., Schroen, B., & Cosemans, J. M. E. M. (2025). Immuno-haemostatic dysregulation in heart failure with preserved ejection fraction. Esc heart failure, 12(5), 3444-3460. https://doi.org/10.1002/ehf2.15361
    • Weerts, J., Schroen, B. L. M., Barandiaran Aizpurua, A., Berendschot, T. T. J. M., Brandts, L., Webers, C. A. B., Simons, S. O., Meex, S. J. R., Henry, R., van der Kallen, C. J. H., Brunner-La Rocca, H.-P., Knackstedt, C., Heymans, S. R. B., de Boer, R. A., van Empel, V. P. M., & Houben, A. J. H. M. (2025). Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study. Cardiovascular Diabetology, 24(1), Article 310. https://doi.org/10.1186/s12933-025-02850-1
    • D'Italia, G., Schroen, B., & Cosemans, J. M. E. M. (2025). Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities. Esc heart failure, 12(2), 1013-1028. Article 15090. https://doi.org/10.1002/ehf2.15090
  • 2024
    • Jusic, A., Erpapazoglou, Z., Dalgaard, L. T., Lakkisto, P., de Gonzalo-Calvo, D., Benczik, B., Ágg, B., Ferdinandy, P., Fiedorowicz, K., Schroen, B., Lazou, A., Devaux, Y., & AtheroNET COST Action CA21153 (2024). Guidelines for mitochondrial RNA analysis. Molecular Therapy - Nucleic Acids, 35(3), Article 102262. https://doi.org/10.1016/j.omtn.2024.102262
  • 2023
    • van Nieuwenhoven, F. A., Schroen, B., Barile, L., van Middendorp, L., Prinzen, F. W., & Auricchio, A. (2023). Plasma Extracellular Vesicles as Liquid Biopsy to Unravel the Molecular Mechanisms of Cardiac Reverse Remodeling Following Resynchronization Therapy?Journal of Clinical Medicine, 12(2), Article 665. https://doi.org/10.3390/jcm12020665
  • 2022
    • Weerts, J., Mourmans, S. G. J., Barandiaran Aizpurua, A., Schroen, B. L. M., Knackstedt, C., Eringa, E., Houben, A. J. H. M., & van Empel, V. P. M. (2022). The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction. Biomolecules, 12(2), Article 278. https://doi.org/10.3390/biom12020278
  • 2021
    • De Majo, F., Martens, L., Hegenbarth, J. C., Ruhle, F., Hamczyk, M. R., Nevado, R. M., Andres, V., Hilbold, E., Bar, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A. S., Stoll, M., & De Windt, L. J. (2021). Genomic instability in the naturally and prematurely aged myocardium. Proceedings of the National Academy of Sciences of the United States of America, 118(36), Article e2022974118. https://doi.org/10.1073/pnas.2022974118
  • 2020
    • Robinson, E. L., Gomes, C. P. C., Potocnjak, I., Hellemans, J., Betsou, F., de Gonzalo-Calvo, D., Stoll, M., Yilmaz, M. B., Agg, B., Beis, D., Carmo-Fonseca, M., Enguita, F. J., Dogan, S., Tuna, B. G., Schroen, B., Ammerlaan, W., Kuster, G. M., Carpusca, I., Pedrazzini, T., ... EU-CardioRNA COST Action (2020). A Year in the Life of the EU-CardioRNA COST Action: CA17129 Catalysing Transcriptomics Research in Cardiovascular Disease. Non-coding RNA, 6(2), Article 17. https://doi.org/10.3390/ncrna6020017
    • Suthahar, N., Meems, L. M. G., van Veldhuisen, D. J., Walter, J. E., Gansevoort, R. T., Heymans, S., Schroen, B., van der Harst, P., Kootstra-Ros, J. E., van Empel, V., Mueller, C., Bakker, S. J. L., & de Boer, R. A. (2020). High-Sensitivity Troponin-T and Cardiovascular Outcomes in the Community: Differences Between Women and Men. Mayo Clinic Proceedings, 95(6), 1158-1168. https://doi.org/10.1016/j.mayocp.2020.01.017
    • De Majo, F., Hegenbarth, J.-C., Ruehle, F., Baer, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A.-S., Stoll, M., & De Windt, L. J. (2020). Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts. Scientific Reports, 10(1), Article 8136. https://doi.org/10.1038/s41598-020-65115-9
    • Liapi, E., van Bilsen, M., Verjans, R., & Schroen, B. (2020). tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function. Biochimica et Biophysica Acta-Molecular Cell Research, 1867(3), Article 118465. https://doi.org/10.1016/j.bbamcr.2019.03.012
    • Verjans, R., van Bilsen, M., & Schroen, B. (2020). Reviewing the Limitations of Adult Mammalian Cardiac Regeneration: Noncoding RNAs as Regulators of Cardiomyogenesis. Biomolecules, 10(2), Article 262. https://doi.org/10.3390/biom10020262
    • Gomes, C. P. C., Schroen, B., Kuster, G. M., Robinson, E. L., Ford, K., Squire, I. B., Heymans, S., Martelli, F., Emanueli, C., Devaux, Y., & EU-CardioRNA COST Action (CA17129) (2020). Regulatory RNAs in Heart Failure. Circulation, 141(4), 313-328. https://doi.org/10.1161/CIRCULATIONAHA.119.042474
  • 2019
    • Kenneweg, F., Bang, C., Xiao, K., Boulanger, C. M., Loyer, X., Mazlan, S., Schroen, B., Hermans-Beijnsberger, S., Foinquinos, A., Hirt, M. N., Eschenhagen, T., Funcke, S., Stojanovic, S., Genschel, C., Schimmel, K., Just, A., Pfanne, A., Scherf, K., Dehmel, S., ... Thum, T. (2019). Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis. Molecular Therapy - Nucleic Acids, 18, 363-374. https://doi.org/10.1016/j.omtn.2019.09.003
    • Verjans, R., Derks, W. J. A., Korn, K., Soennichsen, B., van Leeuwen, R. E. W., Schroen, B., van Bilsen, M., & Heymans, S. (2019). Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure. Scientific Reports, 9(1), Article 6055. https://doi.org/10.1038/s41598-019-41491-9
    • Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M., & Schroen, B. (2019). AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism. Molecular Therapy - Nucleic Acids, 14, 424-437. https://doi.org/10.1016/j.omtn.2018.12.010
  • 2018
    • Aizpurua, A. B., Schroen, B., van Bilsen, M., & van Empel, V. (2018). Targeted HFpEF therapy based on matchmaking of human and animal models. American Journal of Physiology-heart and Circulatory Physiology, 315(6), H1670-H1683. https://doi.org/10.1152/ajpheart.00024.2018
    • Vasques-Novoa, F., Laundos, T. L., Cerqueira, R. J., Quina-Rodrigues, C., Soares-dos-Reis, R., Baganha, F., Ribeiro, S., Mendonca, L., Goncalves, F., Reguenga, C., Verhesen, W., Carneiro, F., Paiva, J. A., Schroen, B., Castro-Chaves, P., Pinto-do-O, P., Nascimento, D. S., Heymans, S., Leite-Moreira, A. F., & Roncon-Albuquerque, R. (2018). MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock. Critical Care Medicine, 46(9), E945-E954. https://doi.org/10.1097/CCM.0000000000003296
    • Hermans-Beijnsberger, S., van Bilsen, M., & Schroen, B. (2018). Long non-coding RNAs in the failing heart and vasculature. Non-coding RNA research, 3(3), 118-130. https://doi.org/10.1016/j.ncrna.2018.04.002
    • Suthahar, N., Meijers, W. C., Ho, J. E., Gansevoort, R. T., Voors, A. A., van der Meer, P., Bakker, S. J. L., Heymans, S., van Empel, V., Schroen, B., van der Harst, P., van Veldhuisen, D. J., & de Boer, R. A. (2018). Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population. European journal of heart failure, 20(8), 1205-1214. https://doi.org/10.1002/ejhf.1209
    • Rech, M., Aizpurua, A. B., van Empel, V., van Bilsen, M., & Schroen, B. (2018). Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle. Cardiovascular Research, 114(6), 782-793. https://doi.org/10.1093/cvr/cvy049
    • Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A., & Schroen, B. (2018). MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure. Hypertension, 71(2), 280-288. https://doi.org/10.1161/HYPERTENSIONAHA.117.10094
    • Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B., & Nabben, M. (2018). Assessing fatty acid oxidation flux in rodent cardiomyocyte models. Scientific Reports, 8(1), Article 1505. https://doi.org/10.1038/s41598-018-19478-9
  • 2017
    • van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B., & van Bilsen, M. (2017). Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling. Scientific Reports, 7(1), Article 16042. https://doi.org/10.1038/s41598-017-16201-y
    • Heggermont, W. A., Papageorgiou, A.-P., Quaegebeur, A., Deckx, S., Carai, P., Verhesen, W., Eelen, G., Schoors, S., van Leeuwen, R., Alekseev, S., Elzenaar, I., Vinckier, S., Pokreisz, P., Walravens, A.-S., Gijsbers, R., Van Den Haute, C., Nickel, A., Schroen, B., van Bilsen, M., ... Heymans, S. (2017). Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. Circulation, 136(8), 747-761. https://doi.org/10.1161/CIRCULATIONAHA.116.024171
    • Steinbusch, M. M. F., Caron, M. M. J., Surtel, D. A. M., Friedrich, F., Lausch, E., Pruijn, G. J. M., Verhesen, W., Schroen, B. L. M., van Rhijn, L. W., Zabel, B., & Welting, T. J. M. (2017). Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation. Scientific Reports, 7(1), Article 6440. https://doi.org/10.1038/s41598-017-06809-5
    • Micheletti, R., Plaisance, I., Abraham, B. J., Sarre, A., Ting, C.-C., Alexanian, M., Maric, D., Maison, D., Nemir, M., Young, R. A., Schroen, B., Gonzalez, A., Ounzain, S., & Pedrazzini, T. (2017). The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Science Translational Medicine, 9(395), Article eaai9118. https://doi.org/10.1126/scitranslmed.aai9118
    • McDermott-Roe, C., Leleu, M., Rowe, G. C., Palygin, O., Bukowy, J. D., Kuo, J., Rech, M., Hermans-Beijnsberger, S., Schaefer, S., Adami, E., Creemers, E. E., Heinig, M., Schroen, B., Arany, Z., Petretto, E., & Geurts, A. M. (2017). Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. PLOS ONE, 12(2), Article 0170458. https://doi.org/10.1371/journal.pone.0170458
  • 2016
    • Gast, M., Schroen, B., Voigt, A., Haas, J., Kuehl, U., Lassner, D., Skurk, C., Escher, F., Wang, X., Kratzer, A., Michalik, K., Papageorgiou, A., Peters, T., Loebel, M., Wilk, S., Althof, N., Prasanth, K. V., Katus, H., Meder, B., ... Poller, W. (2016). Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity. Journal of Molecular Cell Biology, 8(2), 178-181. https://doi.org/10.1093/jmcb/mjw003
    • Peters, T., Beijnsberger, S., Beqqali, A., Bitsch, N., Nakagawa, S., Prasanth, K. V., de Windt, L. J., van Oort, R. J., Heymans, S., & Schroen, B. (2016). Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice. PLOS ONE, 11(2), Article e0150236. https://doi.org/10.1371/journal.pone.0150236
    • Van Aelst, L. N. L., Summer, G., Li, S., Gupta, S. K., Heggermont, W., De Vusser, K., Carai, P., Naesens, M., Van Cleemput, J., Van de Werf, F., Vanhaecke, J., Thum, T., Waer, M., Papageorgiou, A. .-P., Schroen, B., & Heymans, S. (2016). RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection. American Journal of Transplantation, 16(1), 99-110. https://doi.org/10.1111/ajt.13421
  • 2015
    • Ounzain, S., Micheletti, R., Arnan, C., Plaisance, I., Cecchi, D., Schroen, B., Reverter, F., Alexanian, M., Gonzales, C., Ng, S. Y., Bussotti, G., Pezzuto, I., Notredame, C., Heymans, S., Guigo, R., Johnson, R., & Pedrazzini, T. (2015). CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis. Journal of Molecular and Cellular Cardiology, 89, 98-112. https://doi.org/10.1016/j.yjmcc.2015.09.016
    • Corsten, M., Heggermont, W., Papageorgiou, A.-P., Deckx, S., Tijsma, A., Verhesen, W., van Leeuwen, R., Carai, P., Thibaut, H.-J., Custers, K., Summer, G., Hazebroek, M., Verheyen, F., Neyts, J., Schroen, B., & Heymans, S. (2015). The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis. European Heart Journal, 36(42), 2909-U56. https://doi.org/10.1093/eurheartj/ehv321
    • Devaux, Y., Zangrando, J., Schroen, B., Creemers, E. E., Pedrazzini, T., Chang, C.-P., Dorn, G. W. . II., Thum, T., & Heymans, S. (2015). Long noncoding RNAs in cardiac development and ageing. Nature Reviews Cardiology, 12(7), 415-425. https://doi.org/10.1038/nrcardio.2015.55
    • Ounzain, S., Micheletti, R., Beckmann, T., Schroen, B., Alexanian, M., Pezzuto, I., Crippa, S., Nemir, M., Sarre, A., Johnson, R., Dauvillier, J., Burdet, F., Ibberson, M., Guigo, R., Xenarios, I., Heymans, S., & Pedrazzini, T. (2015). Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs. European Heart Journal, 36(6), 353–368. https://doi.org/10.1093/eurheartj/ehu180
  • 2014
    • Tijsen, A. J., van der Made, I., van den Hoogenhof, M. M., Wijnen, W. J., van Deel, E. D., de Groot, N. E., Alekseev, S., Fluiter, K., Schroen, B., Goumans, M.-J., van der Velden, J., Duncker, D. J., Pinto, Y. M., & Creemers, E. E. (2014). The microRNA-15 family inhibits the TGF beta-pathway in the heart. Cardiovascular Research, 104(1), 61-71. https://doi.org/10.1093/cvr/cvu184
    • Peters, T., & Schroen, B. (2014). Missing links in cardiology: long non-coding RNAs enter the arena. Pflugers Archiv-European Journal of Physiology, 466(6), 1177-1187. https://doi.org/10.1007/s00424-014-1479-1
    • Beaumont, J., Lopez, B., Hermida, N., Schroen, B., Jose, G. S., Heymans, S., Valencia, F., Jose Gomez-Doblas, J., De Teresa, E., Diez, J., & Gonzalez, A. (2014). microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation. Clinical Science, 126(7-8), 497-506. https://doi.org/10.1042/CS20130538
  • 2013
    • Heymans, S., Corsten, M. F., Verhesen, W., Carai, P., van Leeuwen, R. E., Custers, K., Peters, T., Hazebroek, M., Stoger, L., Wijnands, E., Janssen, B. J., Creemers, E. E., Pinto, Y. M., Grimm, D., Schurmann, N., Vigorito, E., Thum, T., Stassen, F. R., Yin, X., ... Schroen, B. L. (2013). Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure. Circulation, 128(13), 1420-1432. https://doi.org/10.1161/CIRCULATIONAHA.112.001357
  • 2012
    • Corsten, M. F., Schroen, B., & Heymans, S. (2012). Inflammation in viral myocarditis: friend or foe?Trends in Molecular Medicine, 18(7), 426-437. https://doi.org/10.1016/j.molmed.2012.05.005
    • Donners, M. M. P. C., Wolfs, I. M. J., Stoger, L. J., van der Vorst, E. P. C., Pottgens, C. C. H., Heymans, S., Schroen, B., Gijbels, M. J. J., & de Winther, M. P. J. (2012). Hematopoietic miR155 Deficiency Enhances Atherosclerosis and Decreases Plaque Stability in Hyperlipidemic Mice. PLOS ONE, 7(4), Article e35877. https://doi.org/10.1371/journal.pone.0035877
    • Schroen, B., & Heymans, S. (2012). Small but smart-microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing. Cardiovascular Research, 93(4), 605-613. https://doi.org/10.1093/cvr/cvr268
    • Devaux, Y., Vausort, M., Goretti, E., Nazarov, P. V., Azuaje, F., Gilson, G., Corsten, M. F., Schroen, B., Lair, M.-L., Heymans, S., & Wagner, D. R. (2012). Use of Circulating MicroRNAs to Diagnose Acute Myocardial Infarction. Clinical Chemistry, 58(3), 559-567. https://doi.org/10.1373/clinchem.2011.173823
  • 2011
    • van Almen, G. C., Verhesen, W., van Leeuwen, R. E. W., van de Vrie, M., Eurlings, C., Schellings, M. W. M., Swinnen, M., Cleutjens, J. P. M., van Zandvoort, M. A. M. J., Heymans, S., & Schroen, B. (2011). MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. Aging Cell, 10(5), 769-779. https://doi.org/10.1111/j.1474-9726.2011.00714.x
    • van Almen, G. C., Swinnen, M., Carai, P., Verhesen, W., Cleutjens, J. P. M., D'hooge, J., Verheyen, F. K., Pinto, Y. M., Schroen, B., Carmeliet, P., & Heymans, S. (2011). Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy. Journal of Molecular and Cellular Cardiology, 51(3), 318-328. https://doi.org/10.1016/j.yjmcc.2011.05.010
    • van de Vrie, M., Heymans, S., & Schroen, B. (2011). MicroRNA Involvement in Immune Activation During Heart Failure. Cardiovascular Drugs and Therapy, 25(2), 161-170. https://doi.org/10.1007/s10557-011-6291-y
  • 2006
    • van Haaften, R. I. M., Schroen, B. L., Janssen, B. J., van Erk, A. A., Debets, J. J., Smeets, H. J., Smits, J. F., van den Wijngaard, A., Pinto, Y. M., & Evelo, C. T. (2006). Biologically relevant effects of mRNA amplification on gene expression profiles. BMC Bioinformatics, 7, 200. https://doi.org/10.1186/1471-2105-7-200
  • 2004
    • Sharma, U. C., Pokharel, S., van Brakel, T. J., van Berlo, J. H., Cleutjens, J. P. M., Schroen, B., André, S., Crijns, H. J. G. M., Gabius, H.-J., Maessen, J., & Pinto, Y. M. (2004). Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation, 110(19), 3121-8. https://doi.org/10.1161/01.CIR.0000147181.65298.4D
    • Schroen, B., Heymans, S., Sharma, U., Blankesteijn, W. M., Pokharel, S., Cleutjens, J. P. M., Porter, J. G., Evelo, C. T. A., Duisters, R., van Leeuwen, R. E. W., Janssen, B. J. A., Debets, J. J. M., Smits, J. F. M., Daemen, M. J. A. P., Crijns, H. J. G. M., Bornstein, P., & Pinto, Y. M. (2004). Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circulation Research, 95(5), 515-522. https://doi.org/10.1161/01.RES.0000141019.20332.3e
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