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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Miranda Nabben

Assistant Professor

Dr. Miranda Nabben obtained her MSc in Pharmaceutical Sciences (Utrecht University) and PhD in Human Biology (Maastricht University). She performed postdoctoral research at the University of Washington, Seattle, and at Eindhoven University of Technology, before returning to Maastricht University, where she was appointed Assistant Professor in 2019 and since 2025 holds a joint position in Cardiology and Clinical Genetics.

Her research team investigates cardiac substrate metabolism and metabolic remodeling in heart failure, with a particular focus on fuel flexibility, patterns of substrate utilization, and sex-specific mechanisms, aiming to uncover novel therapeutic targets to improve patient outcomes. She has received multiple grants and awards, including the Kootstra Talent Award, VENI fellowship, NWO Off Road Award, and the Dekker Senior Scientist Award from the Dutch Heart Foundation. Current projects focus on cellular regulation of cardiomyocyte metabolism, metabolic changes in cardiomyopathies, and identification of novel drivers of heart failure.

Dr. Nabben actively contributes to national and European research networks, including the DCVA Double Dose consortium and the ERA4Health Cardinnov project. She has been a board member of the International Society for Heart and Vascular Metabolism (SHVM), is board member of CARIM Division Heart, and serves on the editorial boards of Frontiers in Cardiovascular Medicine and the International Journal of Molecular Sciences. She is committed to mentoring young researchers and has supervised multiple PhD students, postdoctoral fellows, and technicians.

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  • 2025
    • Stroeks, S. L. V. M., Merlo, M., Mora-Ayestaran, N., Jason, M., Tayal, U., Wang, P., Cannatà, A., Sikking, M. A., Dal Ferro, M., Peiro, B., Willemars, M., Hellebrekers, D. M. E. I., van Leeuwen, R. E. W., Setti, M., Gonzalez-Lopez, E., Krapels, I. P. C., Pio Loco Detto Gava, C., van den Wijngaard, A., Henkens, M. T. H. M., ... Verdonschot, J. A. J. (2025). Sex Differences in Prognosis of Patients With Genetic Dilated Cardiomyopathy. Circulation-Heart Failure, 18(11), e012592. Article 012592. https://doi.org/10.1161/CIRCHEARTFAILURE.124.012592
    • Wong, L. Y., Torfs, T., Vanherle, S. J. V., Janssen, J., Claes, G. R. F., Stroeks, S. L. V. M., Willemars, M. M. A., Schianchi, F., Kapsokalyvas, D., Weltjens, E., Swinnen, A., Strzelecka, A., Krapels, I. P. C., Heymans, S. R. B., Glatz, J., van den Wijngaard, A., Brunner, H. G., Broers, J., Luiken, J. F. P., ... Nabben, M. (2025). Clinical and metabolic consequences of a historic pathogenic lamin A/C founder variant. Scientific Reports, 15(1), Article 23842. https://doi.org/10.1038/s41598-025-08495-0
    • Michel, L. Y. M., Esfahani, H., De Mulder, D., Verdoy, R., Ambroise, J., Roelants, V., Bouchard, B., Fabian, N., Savary, J., Dewulf, J. P., Doumont, T., Bouzin, C., Haufroid, V., Luiken, J. J. F. P., Nabben, M., Singleton, M. L., Bertrand, L., Ruiz, M., Des Rosiers, C., & Balligand, J.-L. (2025). An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress. Circulation, 151(18), 1312-1328. https://doi.org/10.1161/CIRCULATIONAHA.124.067876
  • 2024
    • Wang, F., Neumann, D., Kapsokalyvas, D., Hoes, M. F., Schianchi, F., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2024). Specific Compounds Derived from Traditional Chinese Medicine Ameliorate Lipid-Induced Contractile Dysfunction in Cardiomyocytes. International Journal of Molecular Sciences, 25(15), Article 8131. https://doi.org/10.3390/ijms25158131
    • Wang, S., Han, Y., Liu, R., Hou, M., Neumann, D., Zhang, J., Wang, F., Li, Y., Zhao, X., Schianchi, F., Dai, C., Liu, L., Nabben, M., Glatz, J. F. C., Wu, X., Lu, X., Li, X., & Luiken, J. J. F. P. (2024). Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis. Circulation Research, 134(5), 505-525. https://doi.org/10.1161/CIRCRESAHA.123.322910
    • Oberman, K., van Leeuwen, B. L., Nabben, M., Villafranca, J. E., & Schoemaker, R. G. (2024). J147 Affects Cognition And Anxiety After Surgery In Zucker Rats. Physiology & Behavior, 273, Article 114413. https://doi.org/10.1016/j.physbeh.2023.114413
  • 2023
    • Verdonschot, J. A. J., Wang, P., Derks, K. W. J., Adriaens, M. E., Stroeks, S. L. V. M., Henkens, M. T. H. M., Raafs, A. G., Sikking, M., de Koning, B., van den Wijngaard, A., Krapels, I. P. C., Nabben, M., Brunner, H. G., & Heymans, S. R. B. (2023). Clustering of Cardiac Transcriptome Profiles Reveals Unique Subgroups of Dilated Cardiomyopathy Patients. JACC: Basic to Translational Science, 8(4), 406-418. https://doi.org/10.1016/j.jacbts.2022.10.010
    • Stroeks, S. L. V. M., Lunde, I. G. G., Hellebrekers, D. M. E. I., Claes, G. R. F., Wakimoto, H., Gorham, J., Krapels, I. P. C., Vanhoutte, E. K. K., van den Wijngaard, A., Henkens, M. T. H. M., Raafs, A. G. G., Sikking, M. A. A., Broers, J. L. V., Nabben, M., Jones, E. A. V., Heymans, S. R. B., Brunner, H. G. G., & Verdonschot, J. A. J. (2023). Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy. Circulation: Genomic and Precision Medicine, 16(2), Article e003788. https://doi.org/10.1161/CIRCGEN.122.003788
  • 2022
    • Wang, S., Neumann, D., Westenbrink, B. D., Schianchi, F., Wong, L.-Y., Sun, A., Strzelecka, A., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2022). Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly-Rescue by Specific Amino Acid Supplementation. International journal of molecular sciences, 23(21), Article 12909. https://doi.org/10.3390/ijms232112909
    • Willemars, M. M. A., Nabben, M., Verdonschot, J. A. J., & Hoes, M. F. (2022). Evaluation of the Interaction of Sex Hormones and Cardiovascular Function and Health. Current Heart Failure Reports, 19(4), 200-212. https://doi.org/10.1007/s11897-022-00555-0
    • Vuckovic, S., Dinani, R., Nollet, E. E., Kuster, D. W. D., Buikema, J. W., Houtkooper, R. H., Nabben, M., van der Velden, J., & Goversen, B. (2022). Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling. Stem Cell Research & Therapy, 13(1), Article 332. https://doi.org/10.1186/s13287-022-03021-9
    • Wang, S. J., Han, Y. Y., Nabben, M., Neumann, D., Luiken, J. J. F. P., & Glatz, J. F. C. (2022). Endosomal v-ATPase as a Sensor Determining Myocardial Substrate Preference. Metabolites, 12(7), Article 579. https://doi.org/10.3390/metabo12070579
    • Heather, L. C., Hafstad, A. D., Halade, G. V., Harmancey, R., Mellor, K. M., Mishra, P. K., Mulvihill, E. E., Nabben, M., Nakamura, M., Rider, O. J., Ruiz, M., Wende, A. R., & Ussher, J. R. (2022). Guidelines on Models of Diabetic Heart Disease. American Journal of Physiology-heart and Circulatory Physiology, 323(1), H176-H200. https://doi.org/10.1152/ajpheart.00058.2022
    • Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2022). CD36 (SR-B2) as master regulator of cellular fatty acid homeostasis. Current Opinion in Lipidology, 33(2), 103-111. https://doi.org/10.1097/MOL.0000000000000819
    • Glatz, J., Wang, F., Nabben, M., & Luiken, J. (2022). Myocardial lipid metabolism: Targeting CD36 to treat cardiac disease. Research Outreach, (128), 86-89. https://researchoutreach.org/publications/issue-128/
  • 2021
    • Wang, S. J., Schianchi, F., Neumann, D., Wong, L. Y., Sun, A. M., van Nieuwenhoven, F. A., Zeegers, M. P., Strzelecka, A., Col, U., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2021). Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis. Molecular Metabolism, 53, Article 101293. https://doi.org/10.1016/j.molmet.2021.101293
    • Kapsokalyvas, D., Rosas, R., Janssen, R. W. A., Vanoevelen, J. M., Nabben, M., Strauch, M., Merhof, D., & van Zandvoort, M. A. M. J. (2021). Multiview deconvolution approximation multiphoton microscopy of tissues and zebrafish larvae. Scientific Reports, 11(1), Article 10160. https://doi.org/10.1038/s41598-021-89566-w
    • Glatz, J. F. C., Wang, F., Nabben, M., & Luiken, J. J. F. P. (2021). CD36 as a target for metabolic modulation therapy in cardiac disease. Expert Opinion on Therapeutic Targets, 25(5), 393-400. https://doi.org/10.1080/14728222.2021.1941865
    • Wong, L., Glatz, J. F. C., Wang, S., Geraets, I. M. E., Vanherle, S., van den Wijngaard, A., Brunner, H., Luiken, J. J. F. P., & Nabben, M. (2021). Comparison of human and rodent cell models to study myocardial lipid-induced insulin resistance. Prostaglandins Leukotrienes and Essential Fatty Acids, 167, Article 102267. https://doi.org/10.1016/j.plefa.2021.102267
    • Geraets, I. M. E., Coumans, W. A., Strzelecka, A., Schonleitner, P., Antoons, G., Schianchi, F., Willemars, M. M. A., Kapsokalyvas, D., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2021). Metabolic Interventions to Prevent Hypertrophy-Induced Alterations in Contractile Properties In Vitro. International journal of molecular sciences, 22(7), Article 3620. https://doi.org/10.3390/ijms22073620
    • Sun, A., Simsek Papur, O., Dirkx, E., Wong, L., Sips, T., Wang, S., Strzelecka, A., Nabben, M., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2021). Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes. Cellular and Molecular Life Sciences, 78(6), 2839-2856. https://doi.org/10.1007/s00018-020-03669-7
  • 2020
    • Schianchi, F., Glatz, J. F. C., Navarro Gascon, A., Nabben, M., Neumann, D., & Luiken, J. J. F. P. (2020). Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance. International journal of molecular sciences, 21(24), Article 9438. https://doi.org/10.3390/ijms21249438
    • Luiken, J. J. F. P., Nabben, M., Neumann, D., & Glatz, J. F. C. (2020). Understanding the distinct subcellular trafficking of CD36 and GLUT4 during the development of myocardial insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1866(7), Article 165775. https://doi.org/10.1016/j.bbadis.2020.165775
    • Glatz, J. F. C., Nabben, M., Young, M. E., Schulze, P. C., Taegtmeyer, H., & Luiken, J. J. F. P. (2020). Re-balancing cellular energy substrate metabolism to mend the failing heart. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1866(5), Article 165579. https://doi.org/10.1016/j.bbadis.2019.165579
    • Holwerda, A. M., Bouwman, F. G., Nabben, M., Wang, P., van Kranenburg, J., Gijsen, A. P., Burniston, J. G., Mariman, E. C. M., & van Loon, L. J. C. (2020). Endurance-Type Exercise Increases Bulk and Individual Mitochondrial Protein Synthesis Rates in Rats. International Journal of Sport Nutrition and Exercise Metabolism, 30(2), 153-164. https://doi.org/10.1123/ijsnem.2019-0281
    • Wang, S., Wong, L.-Y., Neumann, D., Liu, Y., Sun, A., Antoons, G., Strzelecka, A., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2020). Augmenting Vacuolar H+-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction. International journal of molecular sciences, 21(4), Article 1520. https://doi.org/10.3390/ijms21041520
    • Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2020). CD36 (SR-B2) as a Target to Treat Lipid Overload-Induced Cardiac Dysfunction. Journal of lipid and atherosclerosis, 9(1), 66-78. https://doi.org/10.12997/jla.2020.9.1.66
    • Glatz, J., Luiken, J., & Nabben, M. (2020). Metabolic Modulation to Treat Cardiac Diseases: Role for Membrane Substrate Transporters. Journal of Cardiology and Cardiovascular Sciences, 4(1), 24-29. https://doi.org/10.29245/2578-3025/2020/1.1187
    • Glatz, J., Nabben, M., & Luiken, J. (2020). Myocardial Fatty Acid-Glucose Fuel Balance as Target to Treat Cardiac Diseases. Cardiology and Cardiovascular Medicine, 4(5), 584-590. https://doi.org/10.26502/fccm.92920154
  • 2019
    • Geraets, I. M. E., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2019). Pivotal role of membrane substrate transporters on the metabolic alterations in the pressure-overloaded heart. Cardiovascular Research, 115(6), 1000-1012. https://doi.org/10.1093/cvr/cvz060
    • Zhong, X., Zhang, Z., Wang, S., Cao, L., Zhou, L., Sun, A., Zhong, Z., & Nabben, M. (2019). Microbial-Driven Butyrate Regulates Jejunal Homeostasis in Piglets During the Weaning Stage. Frontiers in microbiology, 9, Article 3335. https://doi.org/10.3389/fmicb.2018.03335
  • 2018
    • van Weeghel, M., Abdurrachim, D., Nederlof, R., Argmann, C. A., Houtkooper, R. H., Hagen, J., Nabben, M., Denis, S., Ciapaite, J., Kolwicz, S. C., Lopaschuk, G. D., Auwerx, J., Nicolay, K., Des Rosiers, C., Wanders, R. J., Zuurbier, C. J., Prompers, J. J., & Houten, S. M. (2018). Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B. Cardiovascular Research, 114(10), 1324-1334. https://doi.org/10.1093/cvr/cvy089
    • Papur, O. S., Sun, A., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism. Frontiers in Cardiovascular Medicine, 5, Article 65. https://doi.org/10.3389/fcvm.2018.00065
    • Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(5), 1960-1967. https://doi.org/10.1016/j.bbadis.2017.12.025
    • Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B., & Nabben, M. (2018). Assessing fatty acid oxidation flux in rodent cardiomyocyte models. Scientific Reports, 8(1), Article 1505. https://doi.org/10.1038/s41598-018-19478-9
    • Nabben, M., Luiken, J. J. F. P., & Glatz, J. F. C. (2018). Metabolic remodelling in heart failure revisited. Nature Reviews Cardiology, 15(12), 780-780. https://doi.org/10.1038/s41569-018-0115-8
  • 2017
    • Abdurrachim, D., Nabben, M., Hoerr, V., Kuhlmann, M. T., Bovenkamp, P., Ciapaite, J., Geraets, I. M. E., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., Schaefers, M., Nicolay, K., Faber, C., Hermann, S., & Prompers, J. J. (2017). Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovascular Research, 113(10), 1148-1160. https://doi.org/10.1093/cvr/cvx100
    • Liu, Y., Steinbusch, L. K. M., Nabben, M., Kapsokalyvas, D., van Zandvoort, M., Schonleitner, P., Antoons, G., Simons, P. J., Coumans, W. A., Geomini, A., Chanda, D., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2017). Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction. Diabetes, 66(6), 1521-1534. https://doi.org/10.2337/db16-0727
    • Nabben, M., Schmitz, J. P. J., Ciapaite, J., le Clercq, C. M. P., van Riel, N. A., Haak, H. R., Nicolay, K., de Coo, I. F. M., Smeets, H., Praet, S. F., van Loon, L. J., & Prompers, J. J. (2017). Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy. American Journal of Physiology-regulatory Integrative and Comparative Physiology, 312(5), R689-R701. https://doi.org/10.1152/ajpregu.00264.2016
    • Chanda, D., Oligschlaeger, Y., Geraets, I., Liu, Y., Zhu, X., Li, J., Nabben, M., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., & Neumann, D. (2017). 2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes. Journal of Biological Chemistry, 292(17), 7105-7114. https://doi.org/10.1074/jbc.M116.767384
    • Momken, I., Chabowski, A., Dirkx, E., Nabben, M., Jain, S. S., McFarlan, J. T., Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2017). A new leptin-mediated mechanism for stimulating fatty acid oxidation: a pivotal role for sarcolemmal FAT/CD36. Biochemical Journal, 474(1), 149-162. https://doi.org/10.1042/BCJ20160804
  • 2016
    • Luiken, J. J. F. P., Chanda, D., Nabben, M., Neumann, D., & Glatz, J. F. C. (2016). Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1862(12), 2253-2258. https://doi.org/10.1016/j.bbadis.2016.09.004
    • Choi, Y. S., de Mattos, A. B. M., Shao, D., Li, T., Nabben, M., Kim, M., Wang, W., Tian, R., & Kolwicz, S. C. . J. (2016). Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion. Journal of Molecular and Cellular Cardiology, 100, 64-71. https://doi.org/10.1016/j.yjmcc.2016.09.001
    • Glatz, J. F. C., Nabben, M., Heather, L. C., Bonen, A., & Luiken, J. J. F. P. (2016). Regulation of the subcellular trafficking of CD36, a major determinant of cardiac fatty acid utilization. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1861(10), 1461-1471. https://doi.org/10.1016/j.bbalip.2016.04.008
    • Nabben, M., & Neumann, D. (2016). GSK-3 Inhibitors: Anti-Diabetic Treatment Associated with Cardiac Risk?Cardiovascular Drugs and Therapy, 30(3), 233-235. https://doi.org/10.1007/s10557-016-6669-y
    • van Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., Schrauwen, P., Hoeks, J., & Hesselink, M. K. C. (2016). A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats. Scientific Reports, 6, Article 22854. https://doi.org/10.1038/srep22854
  • 2015
    • Neumann, D., Luiken, J. J. F. P., Nabben, M., & Glatz, J. F. C. (2015). Letter by Neumann et al Regarding Article, "Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure". Circulation Research, 116(10), E95-E96. https://doi.org/10.1161/CIRCRESAHA.115.306463
    • Abdurrachim, D., Luiken, J. J. F. P., Nicolay, K., Glatz, J. F. C., Prompers, J. J., & Nabben, M. (2015). Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models. Cardiovascular Research, 106(2), 194-205. https://doi.org/10.1093/cvr/cvv105
Overview