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Social and economic background influences survival in intensive care: Research with societal impact

Social and economic background influences survival in intensive care: Research with societal impact

18 August 2026

A large-scale study by researchers from Maastricht UMC+ and Amsterdam UMC demonstrates that lower socioeconomic status (SES) of patients admitted to Dutch intensive care units contributes to worse survival.

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Fatma Karapinar appointed as Professor in Medication Safety

Fatma Karapinar appointed as Professor in Medication Safety

12 August 2026

As of 1 June 2026, Dr Fatma Karapinar has been appointed Professor of Medication Safety at Maastricht University.

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Carim Maastricht
Carim Maastricht

Publications

Section Barend Mees Section Leon Schurgers Section Elham Bidar
  • 2011
    • Cranenburg, E. C. M., van Spaendonck-Zwarts, K. Y., Bonafe, L., Crettol, L. M., Rodiger, L. A., Dikkers, F. G., van Essen, A. J., Superti-Furga, A., Alexandrakis, E., Vermeer, C., Schurgers, L. J., & Laverman, G. D. (2011). Circulating matrix gamma-carboxyglutamate protein (MGP) species are refractory to vitamin K treatment in a new case of Keutel syndrome. Journal of Thrombosis and Haemostasis, 9(6), 1225-1235. https://doi.org/10.1111/j.1538-7836.2011.04263.x
    • Roijers, R. B., Debernardi, N., Cleutjens, J. P. M., Schurgers, L. J., Mutsaers, P. H. A., & van der Vusse, G. J. (2011). Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries. American Journal of Pathology, 178(6), 2879-2887. https://doi.org/10.1016/j.ajpath.2011.02.004
    • Snoeijs, M. G., Hoogland, P. E. R., Boonen, B. T. C., Coffman, T. M., Peutz-Kootstra, C. J., Buurman, W. A., & van Heurn, L. W. E. (2011). Thromboxane receptor signalling in renal ischemia reperfusion injury.Free Radical Research, 45(6), 699-706. https://doi.org/10.3109/10715762.2011.571686
    • Noordzij, M., Cranenburg, E. M., Engelsman, L. F., Hermans, M. M. H., Boeschoten, E. W., Brandenburg, V. M., Bos, W. J., Kooman, J. P., Dekker, F. W., Ketteler, M., Schurgers, L. J., Krediet, R. T., & Korevaar, J. C. (2011). Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients. Nephrology Dialysis Transplantation, 26(5), 1662-1669. https://doi.org/10.1093/ndt/gfq582
    • Caolo, V., Schulten, H. M., Zhuang, Z. W., Murakami, M., Wagenaar, A., Verbruggen, S., Molin, D. G. M., & Post, M. J. (2011). Soluble Jagged-1 Inhibits Neointima Formation by Attenuating Notch-Herp2 Signaling. Arteriosclerosis Thrombosis and Vascular Biology, 31(5), 1059-U270. https://doi.org/10.1161/ATVBAHA.110.217935
    • Bauwens, M., De Saint-Hubert, M., Devos, E., Deckers, N., Reutelingsperger, C. P. M., Mortelmans, L., Himmelreich, U., Mottaghy, F. M., & Verbruggen, A. M. (2011). Site-specific Ga-68-labeled Annexin A5 as a PET imaging agent for apoptosis. Nuclear Medicine and Biology, 38(3), 381-392. https://doi.org/10.1016/j.nucmedbio.2010.09.008
    • van Breugel, N. H., Bidar, E., Essers, B. A., Nieman, F. H., Accord, R. E., Severens, J. L., Vrakking, R., & Maessen, J. G. (2011). Cost-effectiveness of ablation surgery in patients with atrial fibrillation undergoing cardiac surgery. Interactive Cardiovascular and Thoracic Surgery, 12(3), 394-398. https://doi.org/10.1510/icvts.2010.249482
    • Eckstein, J., Maesen, B., Linz, D., Zeemering, S., van Hunnik, A., Verheule, S., Allessie, M., & Schotten, U. (2011). Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat. Cardiovascular Research, 89(4), 816-824. https://doi.org/10.1093/cvr/cvq336
    • Snoeijs, M. G., van Bijnen, A., Swennen, E. L., Haenen, G. R. M. M., Roberts, L. J., Christiaans, M. H., Peppelenbosch, A. G., Buurman, W. A., & van Heurn, L. W. E. (2011). Tubular Epithelial Injury and Inflammation After Ischemia and Reperfusion in Human Kidney Transplantation. Annals of Surgery, 253(3), 598-604. https://doi.org/10.1097/SLA.0b013e31820d9ae9
    • Jiang, Q., Li, Q., Grand-Pierre, A. E., Schurgers, L. J., & Uitto, J. (2011). Administration of vitamin K does not counteract the ectopic mineralization of connective tissues in Abcc6(-/-) mice, a model for pseudoxanthoma elasticum. Cell Cycle, 10(4), 701-707. https://doi.org/10.4161/cc.10.4.14862
    • de Mooij, Y. M., van den Akker, N. M. S., Bekker, M. N., Bartelings, M. M., van Vugt, J. M. G., & Gittenberger-de Groot, A. C. (2011). Aberrant lymphatic development in euploid fetuses with increased nuchal translucency including Noonan syndrome. Prenatal Diagnosis, 31(2), 159-166. https://doi.org/10.1002/pd.2666
    • Schlieper, G., Westenfeld, R., Krueger, T., Cranenburg, E. C., Magdeleyns, E. J. P., Brandenburg, V. M., Djuric, Z., Damjanovic, T., Ketteler, M., Vermeer, C., Dimkovic, N., Floege, J., & Schurgers, L. J. (2011). Circulating Nonphosphorylated Carboxylated Matrix Gla Protein Predicts Survival in ESRD. Journal of the American Society of Nephrology, 22(2), 387-395. https://doi.org/10.1681/ASN.2010040339
    • Snoeijs, M. G., Vaahtera, L., de Vries, E. E., Schurink, G. W. H., Haenen, G. R. M. M., Peutz-Kootstra, C. J., Buurman, W. A., van Heurn, L. W. E., & Parkkinen, J. (2011). Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation. Transplantation, 92(3), 296-302. https://doi.org/10.1097/TP.0b013e3182247b78
    • Snoeijs, M. G., Matthijsen, R. A., Seeldrayers, S., Marcus, M. A., Daemen, J. W., Peutz-Kootstra, C. J., Buurman, W. A., Schurink, G. W. H., & van Heurn, L. W. E. (2011). Autologous transplantation of ischemically injured kidneys in pigs.Journal of Surgical Research, 171(2), 844-850. https://doi.org/10.1016/j.jss.2010.05.064
    • Hoogland, E. R., Snoeijs, M. G., Winkens, B., Christiaans, M. H., & van Heurn, L. W. (2011). Kidney transplantation from donors after cardiac death: uncontrolled versus controlled donation. American Journal of Transplantation, 11(7), 1427-1434. https://doi.org/10.1111/j.1600-6143.2011.03562.x
    • Oostendorp, M., de Vries, E. E., Slenter, J. M., Peutz-Kootstra, C. J., Snoeijs, M. G., Post, M. J., van Heurn, L. W. E., & Backes, W. H. (2011). MRI of renal oxygenation and function after normothermic ischemia-reperfusion injury.NMR in Biomedicine, 24(2), 194-200. https://doi.org/10.1002/nbm.1572
    • Wind, J., Snoeijs, M. G., van der Vliet, J. A., Winkens, B., Christiaans, M. H. L., Hoitsma, A. J., & van Heurn, L. W. E. (2011). Preservation of kidneys from controlled donors after cardiac death. British Journal of Surgery, 98(9), 1260-1266. https://doi.org/10.1002/bjs.7543
    • de Vries, E. E., Hoogland, E. R., Winkens, B., Snoeijs, M. G., & van Heurn, L. W. E. (2011). Renovascular resistance of machine-perfused DCD kidneys is associated with primary nonfunction. American Journal of Transplantation, 11(12), 2685-2691. https://doi.org/10.1111/j.1600-6143.2011.03755.x
    • Gelsomino, S., Luca, F., Renzulli, A., Rubino, A. S., Romano, S. M., van der Veen, F. H., Carella, R., Maessen, J. G., Gensini, G. F., & Lorusso, R. (2011). Increased Coronary Blood Flow and Cardiac Contractile Efficiency With Intraaortic Balloon Counterpulsation in a Porcine Model of Myocardial Ischemia-Reperfusion Injury. Asaio Journal, 57(5), 375-381. https://doi.org/10.1097/MAT.0b013e31822c1539
  • 2010
    • Caolo, V., van den Akker, N. M. S., Verbruggen, S., Donners, M. M. P. C., Swennen, G., Schulten, H., Waltenberger, J., Post, M. J., & Molin, D. G. M. (2010). Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS. Journal of Biological Chemistry, 285(52), 40681-40689. https://doi.org/10.1074/jbc.M110.176065
    • Rostagno, C., La Meir, M., Gelsomino, S., Ghilli, L., Rossi, A., Carone, E., Braconi, L., Rosso, G., Puggelli, F., Mattesini, A., Stefano, P. L., Padeletti, L., Maessen, J., & Gensini, G. F. (2010). Atrial Fibrillation After Cardiac Surgery: Incidence, Risk Factors, and Economic Burden. Journal of Cardiothoracic and Vascular Anesthesia, 24(6), 952-958. https://doi.org/10.1053/j.jvca.2010.03.009
    • Ceulen, R. P. M., Jagtman, E. A., Sommer, A., Teule, G. J. J., Schurink, G. W. H., & Kemerink, G. J. (2010). Blocking the Saphenofemoral Junction During Ultrasound-Guided Foam Sclerotherapy - Assessment of a Presumed Safety-measure Procedure. European Journal of Vascular and Endovascular Surgery, 40(6), 772-776. https://doi.org/10.1016/j.ejvs.2010.08.010
    • van Hasselt, P. M., de Vries, W., de Vries, E., Kok, K., Cranenburg, E. C. M., de Koning, T. J., Schurgers, L. J., Verkade, H. J., & Houwen, R. H. J. (2010). Hydrolysed Formula Is a Risk Factor for Vitamin K Deficiency in Infants With Unrecognised Cholestasis. Journal of Pediatric Gastroenterology and Nutrition, 51(6), 773-776. https://doi.org/10.1097/MPG.0b013e3181efb0b3
    • Hristova, M., van Beek, C., Schurgers, L. J., Lanske, B., & Danziger, J. (2010). Rapidly Progressive Severe Vascular Calcification Sparing the Kidney Allograft Following Warfarin Initiation. American Journal of Kidney Diseases, 56(6), 1158-1162. https://doi.org/10.1053/j.ajkd.2010.06.017
    • Snoeijs, M. G., Vink, H., Voesten, N., Christiaans, M. H., Daemen, J. W., Peppelenbosch, A. G., Tordoir, J. H. M., Peutz-Kootstra, C. J., Buurman, W. A., Schurink, G. W. H., & van Heurn, E. L. (2010). Acute ischemic injury to the renal microvasculature in human kidney transplantation.American Journal of Physiology-Renal Physiology, 299(5), F1134-F1140. https://doi.org/10.1152/ajprenal.00158.2010
    • Donners, M. P. C., Wolfs, I. M. J., Olieslagers, S., Mohammadi-Motahhari, Z., Tchaikovski, V., Heeneman, S., van Buul, J. D., Caolo, V., Molin, D. G. M., Post, M. J., & Waltenberger, J. (2010). A Disintegrin and Metalloprotease 10 Is a Novel Mediator of Vascular Endothelial Growth Factor: Induced Endothelial Cell Function in Angiogenesis and Is Associated With Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology, 30(11), 2188-U382. https://doi.org/10.1161/ATVBAHA.110.213124
    • Dargaud, Y., Spronk, H. M. H., Leenders, P., Hemker, H. C., & Ten Cate, H. (2010). Monitoring platelet dependent thrombin generation in mice. Thrombosis Research, 126(5), 436-441. https://doi.org/10.1016/j.thromres.2010.08.007
    • Peppelenbosch, A. G., Windsant, I. C. V., Jacobs, M. J., Tordoir, J. H. M., & Schurink, G. W. H. (2010). Open Repair for Ruptured Abdominal Aortic Aneurysm and the Risk of Spinal Cord Ischemia: Review of the Literature and Risk-factor Analysis. European Journal of Vascular and Endovascular Surgery, 40(5), 589-595. https://doi.org/10.1016/j.ejvs.2010.07.024
    • Ueland, T., Gullestad, L., Dahl, C. P., Aukrust, P., Aakhus, S., Solberg, O. G., Vermeer, C., & Schurgers, L. J. (2010). Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis. Journal of Internal Medicine, 268(5), 483-492. https://doi.org/10.1111/j.1365-2796.2010.02264.x
    • Cranenburg, E. C. M., Koos, R., Schurgers, L. J., Magdeleyns, E. J. P., Schoonbrood, T. H. M., Landewe, R. B., Brandenburg, V. M., Bekers, O., & Vermeer, C. (2010). Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thrombosis and Haemostasis, 104(4), 811-822. https://doi.org/10.1160/TH09-11-0786
    • Jellema, R. K., Bomans, P., Deckers, N., Ungethum, L., Reutelingsperger, C. P. M., Hofstra, L., & Frederik, P. M. (2010). Transfection efficiency of lipoplexes for site-directed delivery. Journal of Liposome Research, 20(3), 258-267. https://doi.org/10.3109/08982100903384137
    • Wallin, R., Schurgers, L. J., & Loeser, R. F. (2010). Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes. Osteoarthritis and Cartilage, 18(8), 1096-1103. https://doi.org/10.1016/j.joca.2010.05.013
    • Cosemans, J. M. E. M., Van Kruchten, R., Olieslagers, S., Schurgers, L. J., Verheyen, F. K., Munnix, I. C. A., Waltenberger, J., Angelillo-Scherrer, A., Hoylaerts, M. F., Carmeliet, P., & Heemskerk, J. W. M. (2010). Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. Journal of Thrombosis and Haemostasis, 8(8), 1797-1808. https://doi.org/10.1111/j.1538-7836.2010.03935.x
    • Rennenberg, R. J. M. W., van Varik, B. J., Schurgers, L. J., Hamulyak, K., ten Cate, H., Leiner, T., Vermeer, C., de Leeuw, P. W., & Kroon, A. A. (2010). Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood, 115(24), 5121-5123. https://doi.org/10.1182/blood-2010-01-264598
    • Vanakker, O. M., Martin, L., Schurgers, L. J., Quaglino, D., Costrop, L., Vermeer, C., Pasquali-Ronchetti, I., Coucke, P. J., & De Paepe, A. (2010). Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome. Laboratory Investigation, 90(6), 895-905. https://doi.org/10.1038/labinvest.2010.68
    • Parker, B. D., Schurgers, L. J., Brandenburg, V. M., Christenson, R. H., Vermeer, C., Ketteler, M., Shlipak, M. G., Whooley, M. A., & Ix, J. H. (2010). The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study. Annals of Internal Medicine, 152(10), 640-648. https://doi.org/10.7326/0003-4819-152-10-201005180-00004
    • Vermeulen Windsant, I. C., Snoeijs, M. G., Hanssen, S. J. P., Altintas, S., Heijmans, J. H., Koeppel, T. A., Schurink, G. W. H., Buurman, W. A., & Jacobs, M. J. H. M. (2010). Hemolysis is associated with acute kidney injury during major aortic surgery.Kidney International, 77(10), 913-920. https://doi.org/10.1038/ki.2010.24
    • Parker, B. D., Schurgers, L. J., Vermeer, C., Schiller, N. B., Whooley, M. A., & Ix, J. H. (2010). The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study. Atherosclerosis, 210(1), 320-325. https://doi.org/10.1016/j.atherosclerosis.2009.11.023
    • Schlieper, G., Grotemeyer, D., Aretz, A., Schurgers, L. J., Krueger, T., Rehbein, H., Weirich, T. E., Westenfeld, R., Brandenburg, V. M., Eitner, F., Mayer, J., Floege, J., Sandmann, W., & Ketteler, M. (2010). Analysis of Calcifications in Patients with Coral Reef Aorta. Annals of Vascular Surgery, 24(3), 408-414. https://doi.org/10.1016/j.avsg.2009.11.006
    • Rennenberg, R. J. M. W., de Leeuw, P. W., Kessels, A. G. H., Schurgers, L. J., Vermeer, C., van Engelshoven, J. M. A., Kemerink, G. J., & Kroon, A. A. (2010). Calcium scores and matrix Gla protein levels: association with vitamin K status. European Journal of Clinical Investigation, 40(4), 344-349. https://doi.org/10.1111/j.1365-2362.2010.02275.x
    • Schurgers, L. J., Barreto, D. V., Barreto, F. C., Liabeuf, S., Renard, C., Magdeleyns, E. J. P., Vermeer, C., Choukroun, G., & Massy, Z. A. (2010). The Circulating Inactive Form of Matrix Gla Protein Is a Surrogate Marker for Vascular Calcification in Chronic Kidney Disease: A Preliminary Report. Clinical journal of the American Society of Nephrology, 5(4), 568-575. https://doi.org/10.2215/CJN.07081009
    • Speelman, L., Hellenthal, F. A., Pulinx, B., Bosboom, E. M. H., Breeuwer, M., Van Sambeek, M. R. H. M., de Vosse, F. N. V., Jacobs, M. J., Wodzig, W. K. W. H., & Schurink, G. W. H. (2010). The Influence of Wall Stress on AAA Growth and Biomarkers. European Journal of Vascular and Endovascular Surgery, 39(4), 410-416. https://doi.org/10.1016/j.ejvs.2009.12.021
    • De Saint-Hubert, M., Mottaghy, F. M., Vunckx, K., Nuyts, J., Fonge, H., Prinsen, K., Stroobants, S., Mortelmans, L., Deckers, N., Hofstra, L., Reutelingsperger, C. P. M., Verbruggen, A. M., & Rattat, D. (2010). Site-specific labeling of 'second generation' annexin V with Tc-99m(CO)(3) for improved imaging of apoptosis in vivo. Bioorganic & Medicinal Chemistry, 18(3), 1356-1363. https://doi.org/10.1016/j.bmc.2009.12.021
    • Rennenberg, R. J. W. M., Schurgers, L. J., Kroon, A. A., & Stehouwer, C. D. A. (2010). Arterial calcifications. Journal of Cellular and Molecular Medicine, 14(9), 2203-2210. https://doi.org/10.1111/j.1582-4934.2010.01139.x
    • Snoeijs, M. G., van Heurn, L. W. E., & Buurman, W. A. (2010). Biological modulation of renal ischemia-reperfusion injury.Current Opinion in Organ Transplantation, 15(2), 190-199. https://doi.org/10.1097/MOT.0b013e32833593eb
    • Hoogland, E. R., Snoeijs, M. G., & van Heurn, L. W. E. (2010). DCD kidney transplantation: results and measures to improve outcome. Current Opinion in Organ Transplantation, 15(2), 177-82. https://doi.org/10.1097/MOT.0b013e32833734b1
    • Snoeijs, M. G., Boonstra, L. A., Buurman, W. A., Goldschmeding, R., van Suylen, R. J., van Heurn, L. W., & Kootstra, C. J. (2010). Histological assessment of pre-transplant kidney biopsies is reproducible and representative. Histopathology, 56(2), 198-202. https://doi.org/10.1111/j.1365-2559.2009.03469.x
    • de Vries, E. E., Snoeijs, M. G., & van Heurn, L. W. E. (2010). Kidney donation from children after cardiac death. Critical Care Medicine, 38(1), 249-253. https://doi.org/10.1097/CCM.0b013e3181c025fd
    • Snoeijs, M. G., Schaubel, D. E., Hene, R., Hoitsma, A. J., Idu, M. M., Ijzermans, J. N., Ploeg, R. J., Ringers, J., Christiaans, M. H., Buurman, W. A., & van Heurn, L. W. (2010). Kidneys from donors after cardiac death provide survival benefit. Journal of the American Society of Nephrology, 21(6), 1015-21. https://doi.org/10.1681/ASN.2009121203
    • Snoeijs, M. G., Winkens, B., Heemskerk, M. B., Hoitsma, A. J., Christiaans, M. H., Buurman, W. A., & van Heurn, L. W. E. (2010). Kidney transplantation from donors after cardiac death: a 25-year experience.Transplantation, 90(10), 1106-1112. https://doi.org/10.1097/TP.0b013e3181f83b0b