PI group Erik Biessen
- 2025
- Peters, L. J. F., Bidzhekov, K., Bonnin-Marquez, A., Sundararaman, S. S., Huchzermeier, R., Maas, S. L., Abschlag, K., Jans, A., Lin, C., Haberbosch, M., Jansen, Y., Yu, B., Sluimer, J. C., Gijbels, M. J., Jankowski, J., Bartneck, M., Biessen, E. A. L., Weber, C., Doring, Y., & Van Der Vorst, E. P. C. (2025). MicroRNA-26b<SUP>-/-</SUP> augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis. Cardiovascular Research, 121(17), 2700-2713. https://doi.org/10.1093/cvr/cvaf234
- Jin, H., Maas, S. L., Zou, Y., Lu, C., Yu, B., Huchzermeier, R., Nadeau, S., Dos Santos, J., Gijbels, M., Mees, B. M. E., Smirnov, E., Matic, L., Hedin, U., Maffia, P., Monaco, C., Sluimer, J. C., Martins, G. A., van der Vorst, E. P. C., & Biessen, E. A. L. (2025). Identification of a PRDM1-regulated T cell network to regulate atherosclerotic plaque inflammation. Genome Medicine, 17(1), Article 109. https://doi.org/10.1186/s13073-025-01541-6
- Bonnin-Marquez, A., Maas, S. L., Corcini-Berndt, M., & van der Vorst, E. P. C. (2025). Unbiased kinome profiling identifies key and novel mediators of chronic kidney disease in hyperlipidemic mice. Frontiers in physiology, 16, Article 1684982. https://doi.org/10.3389/fphys.2025.1684982
- Hall, I. F., Aikawa, E., Sluimer, J., Baker, A. H., & Kovacic, J. C. (2025). Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives. European Heart Journal, Article ehaf670. https://doi.org/10.1093/eurheartj/ehaf670
- Goertzen, L., Heeneman, S., & Schils, T. (2025). The impact of formative assessment on pupil academic achievement: An empirical study of the effects of a formative assessment practices program that was co-designed in a teacher community. Learning and Instruction, 99, Article 102153. https://doi.org/10.1016/j.learninstruc.2025.102153
- Brown, S. D., Malinowska, A. L., Bennett, M., Correa-Sánchez, A. F., Horcasitas Valencia, L. L., Lucignoli, A. P., Barton, A. K., Clark, L., Sluimer, J. C., Webster, S. P., Rodor, J., Newby, D. E., Cunningham, M., & Baker, A. H. (2025). Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure. JACC: Basic to Translational Science, Article 101364. https://doi.org/10.1016/j.jacbts.2025.101364
- Benhmammouch, S., Borowczyk, C., Pierrot-Blanchet, C., Barouillet, T., Murcy, F., Dussaud, S., Blanc, M., Bleriot, C., Ord, T., Habbouche, L., Vaillant, N., Gerber, Y., Cochain, C., Gautier, E. L., Ginhoux, F., Thorp, E. B., Biessen, E. A. L., Sluimer, J. C., Bodoy, S., ... Yvan-Charvet, L. (2025). Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis. Nature Metabolism, 7(9), 1924-1938. https://doi.org/10.1038/s42255-025-01354-2
- Mcdonald, J., Heeneman, S., & Hu, W. (2025). Discoveries or doubts: a qualitative study of the transformative potential of portfolio meetings. Advances in Health Sciences Education, 30(4), 1045-1064. https://doi.org/10.1007/s10459-024-10387-3
- Al-Bualy, R., Heeneman, S., Skipper, M., & Govaerts, M. (2025). The transformative power of a change laboratory: Experiences from an assessment re-design project in Oman. Medical Education. Advance online publication. https://doi.org/10.1111/medu.70012
- Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
- Asselberghs, S. E. J., Halder, M., Kramann, R., & Sluimer, J. C. (2025). Fibroblasts—The emerging therapeutic target of the cardiovascular system?Pharmacological Reviews, 77(4), Article 100072. https://doi.org/10.1016/j.pharmr.2025.100072
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Correction: Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1637511. https://doi.org/10.3389/fimmu.2025.1637511
- Xu, H., & Sluimer, J. (2025). IL-1β inhibition in stabilizing atherosclerotic plaques: The critical role of fibroblast-like cells. Vascular Pharmacology, 159, Article 107493. https://doi.org/10.1016/j.vph.2025.107493
- Sopic, M., Mitic, T., Sluimer, J., Magni, P., Devaux, Y., & AtheroNET COST Action CA 21153 (2025). Editorial: Multiomic approaches in atherosclerosis. Vascular Pharmacology, 159, Article 107501. https://doi.org/10.1016/j.vph.2025.107501
- Yu, B., Sopic, M., & Sluimer, J. C. (2025). Single-cell RNA sequencing (scRNA-seq) and its insights into cellular heterogeneity in atherosclerosis. Vascular Pharmacology, 159, Article 107499. https://doi.org/10.1016/j.vph.2025.107499
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1532250. https://doi.org/10.3389/fimmu.2025.1532250
- Noels, H., van der Vorst, E. P. C., Rubin, S., Emmett, A., Marx, N., Tomaszewski, M., & Jankowski, J. (2025). Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure. Circulation Research, 136(11), 1306-1334. https://doi.org/10.1161/CIRCRESAHA.124.325488
- Chteinberg, E., Kolarova, J., Vogt, J., Macamo, A., Bormann, F., Kretzmer, H., Speel, E. J., van den Oord, J., Schneider, C., Stilgenbauer, S., Becker, J. C., Winnepenninckx, V., Biessen, E., Zenke, M., Kurz, A. K., Siebert, R., & zur Hausen, A. (2025). The significance of PAX5 in Merkel cell carcinoma. Journal of Pathology, 266(1), 81-94. https://doi.org/10.1002/path.6410
- Peters, L., Rakateli, L., Huchzermeier, R., Bonnin-Marquez, A., Maas, S. L., Lin, C., Jans, A., Geng, Y., Gorter, A., Gijbels, M., Rensen, S., Olinga, P., Hendrikx, T., Krawczyk, M., Brisbois, M., Jankowski, J., Bidzhekov, K., Weber, C., Biessen, E. A. L., ... van der Vorst, E. (2025). MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles. Elife, 13. https://doi.org/10.7554/eLife.97165
- van der Vorst, E. P. C., & Lembo, G. (2025). Harnessing the power of the brain to fight metabolic diseases. Cardiovascular Research, 121(5), 685-687. https://doi.org/10.1093/cvr/cvaf061
- Vermeulen, I., Li, M., van Mourik, H., Yadati, T., Eijkel, G., Balluff, B., Godschalk, R., Temmerman, L., Biessen, E. A. L., Kulkarni, A., Theys, J., Houben, T., Cillero-Pastor, B., & Shiri-Sverdlov, R. (2025). Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. FEBS Journal, 292(7), 1781-1797. https://doi.org/10.1111/febs.17358
- Ben-Aicha, S., & van der Vorst, E. P. C. (2025). Shaping the future of cardiovascular research: a focus on cardioimmunology. European Heart Journal, 46(9), 778-780. Article ehae783. https://doi.org/10.1093/eurheartj/ehae783
- Huchzermeier, R., & van der Vorst, E. P. C. (2025). Aryl hydrocarbon receptor (AHR) and nuclear factor erythroid-derived 2-like 2 (NRF2): An important crosstalk in the gut-liver axis. Biochemical Pharmacology, 233, Article 116785. https://doi.org/10.1016/j.bcp.2025.116785
- Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F., ... Westerterp, M. (2025). SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis. Circulation Research, 136(5), 491-507. https://doi.org/10.1161/CIRCRESAHA.124.325103
- Fuentes-Cimma, J., Sluijsmans, D., Mejias, P. P., Villagran, I., Riquelme, A., & Heeneman, S. (2025). Psychometric properties of the Feedback Orientation Scale in the clinical workplace of health professions students. International Journal of Medical Education, 16, 36-44. https://doi.org/10.5116/ijme.679e.07de
- Bink, D. I., Ritz, K., Mackaaij, C., Stam, O., Scheffer, S., Mizee, M. R., Ploegmakers, H. J., van Het Hof, B. J., de Boer, O. J., Sluimer, J., De Meyer, G. R., van der Weerd, L., de Vries, H. E., & Daemen, M. J. (2025). Lack of intracranial atherosclerosis in various atherosclerotic mouse models. Vascular Biology, 7(1), Article e230013. https://doi.org/10.1530/VB-23-0013
- Bleckwehl, T., Babler, A., Tebens, M., Maryam, S., Nyberg, M., Bosteen, M., Halder, M., Shaw, I., Fleig, S., Pyke, C., Hvid, H., Voetmann, L. M., van Buul, J. D., Sluimer, J. C., Das, V., Baumgart, S., Kramann, R., & Hayat, S. (2025). Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis. Nature cardiovascular research, 4(1), 26-44. https://doi.org/10.1038/s44161-024-00582-1
- Lee, A., Jere, A., Du Plessis, L., Van Gerven, P. W. M., Heeneman, S., & Ross, S. (2025). Continuity of supervision: Balancing continuous and episodic relationships for assessment and learning. Medical Education, 59(6), 596-605. https://doi.org/10.1111/medu.15595
- van Mourik, H., Westheim, A., Schneider, C. V., Stoffels, L., Wieczerzak, E., Steeghs, J., Schneider, K. M., Temmerman, L., Biessen, E., Godschalk, R., Theys, J., & Shiri - Sverdlov, R. (2025). Extracellular Cathepsin B Is a potential Therapeutic Target in Hepatocellular Carcinoma. Liver International, 6(1), Article e70016. https://doi.org/10.1002/lci2.70016
- 2024
- Ekpenyong, A., Holmboe, E. S., Govaerts, M., & Heeneman, S. (2024). Investigating the Roles and Impact of Clinical Competency Committees in Graduate Medical Education: A Narrative Review. Journal of Graduate Medical Education, 16(6), 662-683. https://doi.org/10.4300/JGME-D-24-00017.1
- Fuentes-Cimma, J., Sluijsmans, D., Ortega-Bastidas, J., Villagran, I., Riquelme-Perez, A., & Heeneman, S. (2024). Students and Clinical Teachers’ Experiences About Productive Feedback Practices in the Clinical Workplace from a Sociocultural Perspective. International Medical Education, 3(4), 461-472. https://doi.org/10.3390/ime3040035
- Jauregui, J., McClintock, A. H., Schrepel, C., Fainstad, T., Bierer, S. B., & Heeneman, S. (2024). You Get What You Reward: A Qualitative Study Exploring Medical Student Engagement in 2 Different Assessment Systems. Academic Medicine, 99(11), 1278-1285. Article 10.1097/ACM.0000000000005848. https://doi.org/10.1097/ACM.0000000000005848
- Medina, I., Wieland, E. B., Temmerman, L., Otten, J. J. T., Bermudez, B., Bot, I., Rademakers, T., Wijnands, E., Schurgers, L., Mees, B., van Berkel, T. J. C., Goossens, P., & Biessen, E. A. L. (2024). Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics. European Journal of Immunology, 54(11), Article 2350943. https://doi.org/10.1002/eji.202350943
- Kral, M., van der Vorst, E. P. C., Weber, C., & Doering, Y. (2024). (Multi-) omics studies of ILC2s in inflammation and metabolic diseases. Frontiers in Cell and Developmental Biology, 12, Article 1473616. https://doi.org/10.3389/fcell.2024.1473616
- Sluimer, J. C. (2024). Metabolic and Shear Stress Regulate Endothelial Epas1 in Atherosclerosis. Circulation Research, 135(8), 838-840. https://doi.org/10.1161/CIRCRESAHA.124.325131
- Adam, S., Maas, S. L., Huchzermeier, R., Rakateli, L., Abschlag, K., Hohl, M., Liao, L., Bartneck, M., Teunissen, M., Wouters, K., Santovito, D., Jankowski, J., Biessen, E. A. L., & van der Vorst, E. P. C. (2024). The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis. EBioMedicine, 107, Article 105293. https://doi.org/10.1016/j.ebiom.2024.105293
- Dai, Y., Junho, C. V. C., Schieren, L., Wollenhaupt, J., Sluimer, J. C., van der Vorst, E. P. C., & Noels, H. (2024). Cellular metabolism changes in atherosclerosis and the impact of comorbidities. Frontiers in Cell and Developmental Biology, 12, Article 1446964. https://doi.org/10.3389/fcell.2024.1446964
- Mouzakis, F. L., Hima, F., Kashefi, A., Greven, J., Rink, L., van der Vorst, E. P. C., Jankowski, J., Mottaghy, K., & Spillner, J. (2024). Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study. Biomedicines, 12(8), Article 1883. https://doi.org/10.3390/biomedicines12081883
- Rademakers, T., Manca, M., Jin, H., Orban, T., Perisic, L. M., Frissen, H. J. M., Rühle, F., Hautvast, P., van Rijssel, J., van Kuijk, K., Mees, B. M. E., Peutz-Kootstra, C. J., Heeneman, S., Daemen, M. J. A. P., Pasterkamp, G., Stoll, M., van Zandvoort, M. A. M. J., Hedin, U., Dequiedt, F., ... Biessen, E. A. L. (2024). Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype. Angiogenesis, 27(3), 461-474. https://doi.org/10.1007/s10456-024-09921-z
- Wang, F., Neumann, D., Kapsokalyvas, D., Hoes, M. F., Schianchi, F., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2024). Specific Compounds Derived from Traditional Chinese Medicine Ameliorate Lipid-Induced Contractile Dysfunction in Cardiomyocytes. International Journal of Molecular Sciences, 25(15), Article 8131. https://doi.org/10.3390/ijms25158131
- Jin, H., Zhang, C., Nagenborg, J., Juhasz, P., Ruder, A. V., Sikkink, C. J. J. M., Mees, B. M. E., Waring, O., Sluimer, J. C., Neumann, D., Goossens, P., Donners, M. M. P. C., Mardinoglu, A., & Biessen, E. A. L. (2024). Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability. Cardiovascular Diabetology, 23(1), Article 240. https://doi.org/10.1186/s12933-024-02339-3
- Singh, A., Kraaijeveld, A. O., Curaj, A., Wichapong, K., Hammerich, L., de Jager, S. C. A., Bot, I., Atamas, S. P., van Berkel, T. J. C., Jukema, J. W., Comerford, I., Mccoll, S. R., Mees, B., Heemskerk, J. W. M., Nicolaes, G. A. F., Hackeng, T., Liehn, E. A., Tacke, F., & Biessen, E. A. L. (2024). CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization. Frontiers in Immunology, 15, Article 1327051. https://doi.org/10.3389/fimmu.2024.1327051
- Fuentes-Cimma, J., Sluijsmans, D., Riquelme, A., Villagran, I., Isbej, L., Olivares-Labbe, M. T., & Heeneman, S. (2024). Designing feedback processes in the workplace-based learning of undergraduate health professions education: a scoping review. BMC Medical Education, 24(1), Article 440. https://doi.org/10.1186/s12909-024-05439-6
- Harlacher, E., Schulte, C., Vondenhoff, S., Schmitt-Kopplin, P., Diederich, P., Hemmers, C., Moellmann, J., Wollenhaupt, J., Veltrop, R., Biessen, E., Lehrke, M., Peters, B., Schlieper, G., Kuppe, C., Floege, J., Jankowski, V., Marx, N., Jankowski, J., & Noels, H. (2024). Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health. Frontiers in Cardiovascular Medicine, 11, Article 1346475. https://doi.org/10.3389/fcvm.2024.1346475
- Wang, S., Han, Y., Liu, R., Hou, M., Neumann, D., Zhang, J., Wang, F., Li, Y., Zhao, X., Schianchi, F., Dai, C., Liu, L., Nabben, M., Glatz, J. F. C., Wu, X., Lu, X., Li, X., & Luiken, J. J. F. P. (2024). Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis. Circulation Research, 134(5), 505-525. https://doi.org/10.1161/CIRCRESAHA.123.322910
- Cao, J., Martin-Lorenzo, M., van Kuijk, K., Wieland, E., Gijbels, M. J., Claes, B. S. R., Heredero, A., Aldamiz-Echevarria, G., Heeren, R. M. A., Goossens, P., Sluimer, J., Balluff, B., & Alvarez-Llamas, G. (2024). Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation. Arteriosclerosis Thrombosis and Vascular Biology, 44(3), 741-754. https://doi.org/10.1161/ATVBAHA.123.320278
- Lu, C., Donners, M. M. P. C., de Baaij, J. B. J., Jin, H., Otten, J. J. T., Manca, M., van Zonneveld, A. J., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Mees, B., Sluimer, J. C., Cavill, R., Karel, J. M. H., Goossens, P., & Biessen, E. A. L. (2024). Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients. Frontiers in Immunology, 15, Article 1286382. https://doi.org/10.3389/fimmu.2024.1286382




