PI group Paul Volders
- 2025
- Heymans, A. B. M., Bianchi, L., Volders, P. G. A., van der Crabben, S. N., & Verdonschot, J. A. J. (2025). SCN5A Cardiomyopathy: from Ion Channel Dysfunction To Clinical Disease. Current Cardiology Reports, 27(1), Article 138. https://doi.org/10.1007/s11886-025-02298-5
- Gawalko, M., Habibi, Z., Verhaert, D. V. M., Engels, M., Weerts, J., Adriaans, B., Chaldoupi, S.-M., ter Bekke, R. M. A., Den Uijl, D. W., Luermans, J. G. L. M., Van Empel, V. P. M., Schotten, U., Vernooy, K., & Linz, D. (2025). Discordance between left atrial pressure and risk scores in assessment of heart failure with preserved ejection fraction in patients with atrial fibrillation undergoing catheter ablation. EP Europace, 27(10), Article euaf245. https://doi.org/10.1093/europace/euaf245
- Szabo, B. R., Stein, J., Savchenko, A., Hutschalik, T., Van Nieuwerburgh, F., Meese, T., Kosmidis, G., Volders, P. G. A., & Matsa, E. (2025). Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds. Frontiers in Toxicology, 7, Article 1644119. https://doi.org/10.3389/ftox.2025.1644119
- Rivera, S., Ricapito, M. D. L. P., Ronderos, R., & Volders, P. G. A. (2025). Anatomical Determinants of Papillary Muscle Arrhythmias in Apparently Normal Hearts. Arrhythmia & Electrophysiology Review, 14, Article e16. https://doi.org/10.15420/aer.2025.10
- ter Bekke, R. M. A., van Rooij, T., Volders, P. G. A., & Hocini, M. (2025). Targeted ablation of the distal Purkinje-myocardium interface for premature ventricular complex-induced cardiomyopathy by delayed Purkinje conduction-induced re-excitation: a case report. European Heart Journal - Case Reports, 9(8), Article ytaf335. https://doi.org/10.1093/ehjcr/ytaf335
- Oebel, S., Garcia, J. G., Arya, A., Jahnke, C., Paetsch, I., Loebe, S., Bode, K., ter Bekke, R. M. A., Vernooy, K., Dagres, N., Hindricks, G., & Darma, A. (2025). Late gadolinium enhancement imaging for the prediction of ventricular tachycardia ablation outcome. Journal of Interventional Cardiac Electrophysiology, 68(5), 1075-1085. https://doi.org/10.1007/s10840-025-02017-8
- Linz, D., Gulpen, J., Engels, M., Hendriks, J. M., Tjong, F., Mulder, B. A., Weijs, B., Pisters, R., Hemels, M., Ter Bekke, R., Beukema, R., Evens, S., Pürerfellner, H., Merino, J. L., Gunawardene, M., Chun, K.-R. J., & Yap, S.-C. (2025). Digital pulse self-measurement by a photoplethysmography smartphone application in the general population: The "#PulseDay in The Netherlands" awareness campaign. European Journal of Cardiovascular Nursing. Advance online publication. https://doi.org/10.1093/eurjcn/zvaf142
- Clerx, M., Volders, P. G. A., & Mirams, G. R. (2025). Variability in reported midpoints of (in)activation of cardiac INa. Journal of General Physiology, 157(5), Article e202413621. https://doi.org/10.1085/jgp.202413621
- Meier, S., Dobrev, D., Volders, P. G. A., & Heijman, J. (2025). Computational modelling of the pro- and antiarrhythmic effects of atrial high rate-dependent trafficking of small-conductance calcium-activated potassium channels. Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP288659
- Rademaker, R., Cirkel, S., Omara, S., Dankers, F., Sramko, M., Solana Munoz, J., Kaya, Y. S., Ter Bekke, R., Schiappacasse, L., Teres, C., Verhoeven, K., Pruvot, E., Rasch, C., & Zeppenfeld, K. (2025). Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrhythmia radioablation using a commercial software. EP Europace, 27(7), Article euaf122. https://doi.org/10.1093/europace/euaf122
- Smits, K. C., Lempers, T. E. M., Strik, M., Stoks, J., Meiburg, R., Cluitmans, M. J. M., Volders, P. G. A., Vernooy, K., Prinzen, F. W., & Nguyen, U. C. (2025). The influence of delayed ventricular activation on cardiac repolarization: Insights from electrocardiographic imaging. Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP288569
- Ter Bekke, R. M. A., Hohmann, S., Xie, J., Grehn, M., Verhoeven, K., Volders, P. G. A., Mihl, C., Kaya, Y. S., Manninger, M., Scherr, D., Corradini, S., Schweikard, A., Rademaker, R., Hoeksema, W. F., Schiappacasse, L., Knybel, L., Pruvot, E., Postema, P. G., Peichl, P., ... Boda-Heggemann, J. (2025). Transfer of arrhythmia substrate targets from the cardiac electroanatomical and imaging modalities to the planning computed tomography scan for stereotactic arrhythmia radioablation for refractory ventricular tachycardia - a state-of-the-art review on software developments on behalf of the STOPSTORM.eu consortium. Radiotherapy and Oncology, 210, Article 111004. https://doi.org/10.1016/j.radonc.2025.111004
- Manninger, M., Lercher, I., Hermans, A. N. L., Isaksen, J. L., Prassl, A. J., Zirlik, A., Vernooy, K., Chaldoupi, S.-M., Luermans, J., Ter Bekke, R. M. A., Kanters, J. K., Plank, G., Scherr, D., Pock, T., & Linz, D. (2025). Machine-learning guided differentiation between photoplethysmography waveforms of supraventricular and ventricular origin. Computer Methods and Programs in Biomedicine, 267, Article 108798. https://doi.org/10.1016/j.cmpb.2025.108798
- Wang, T., Karel, J., Osnabrugge, N., Driessens, K., Stoks, J., Cluitmans, M., Volders, P., Bonizzi, P., & Peeters, R. (2025). Deep learning based estimation of heart surface potentials. Artificial Intelligence in Medicine, 163, Article 103093. https://doi.org/10.1016/j.artmed.2025.103093
- de Riva, M., Evertz, R., Lukac, P., Dekker, L. R. C., Blaauw, Y., ter Bekke, R. M. A., Kimura, Y., Beukema, R. J., Ouss, A., Mulder, B. A., Vernooy, K., Wijnmaalen, A. P., & Zeppenfeld, K. (2025). Evoked delayed potential ablation for post-myocardial infarction ventricular tachycardia: results from a large prospective multicentre study. EP Europace, 27(2), Article euaf003. https://doi.org/10.1093/europace/euaf003
- Manninger, M., Zweiker, D., Hovakimyan, T., Matusik, P. T., Conti, S., Ollitrault, P., Aro, A., Mulder, B. A., Dichtl, W., Heeger, C. H., ter Bekke, R. M. A., Gul, E. E., Weijs, B., Rahm, A. K., Darma, A., Evranos, B., Sabbag, A., Moroka, K., Traykov, V., ... Linz, D. (2025). Author's Reply to “Digital Devices for Arrhythmia Detection: What Is Still Missing?”. Clinical Cardiology, 48(2), Article e70092. https://doi.org/10.1002/clc.70092
- Deissler, P. M., Volders, P. G. A., & Ter Bekke, R. M. A. (2025). The Electromechanical Window for Arrhythmia-Risk Assessment. Heart Rhythm, 22(1), 118-127. https://doi.org/10.1016/j.hrthm.2024.06.012
- Sobota, V., Stoks, J., Patel, K. H. K., Shetty, R., Ni, H., Grandi, E., Ng, F. S., Volders, P. G. A., Cluitmans, M. J. M., & Bayer, J. D. (2025). The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability. The Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP288356
- 2024
- Manninger, M., Zweiker, D., Hovakimyan, T., Matusik, P. T., Conti, S., Ollitrault, P., Aro, A., Mulder, B. A., Dichtl, W., Heeger, C.-H., Ter Bekke, R., Gul, E. E., Weijs, B., Rahm, A.-K., Darma, A., Evranos, B., Sabbag, A., Moroka, K., Traykov, V., ... Linz, D. (2024). Physician Preferences in Using Novel Digital Devices for the Management of Atrial Fibrillation-A DAS-CAM III Survey. Clinical Cardiology, 47(12), Article e24331. https://doi.org/10.1002/clc.24331
- Tohidinezhad, F., Nürnberg, L., Vaassen, F., Ma Ter Bekke, R., Jwl Aerts, H., El Hendriks, L., Dekker, A., De Ruysscher, D., & Traverso, A. (2024). Prediction of new-onset atrial fibrillation in patients with non-small cell lung cancer treated with curative-intent conventional radiotherapy. Radiotherapy and Oncology, 201, Article 110544. https://doi.org/10.1016/j.radonc.2024.110544
- Patel, K. H. K., Bajaj, N., Statton, B. K., Bishop, M. J., Herath, N. S., Stoks, J., Li, X., Sau, A., Nyamakope, K., Davidson, R., Savvidou, S., Agha-Jaffar, D., Coghlin, J. A., Brezitski, M., Bergman, H., Berry, A., Ardissino, M., de Marvao, A. S. M., Cousins, J., ... Ng, F. S. (2024). Bariatric surgery partially reverses subclinical proarrhythmic structural, electrophysiological, and autonomic changes in obesity. Heart Rhythm, 21(11), 2282-2294. https://doi.org/10.1016/j.hrthm.2024.05.052
- Kaya, Y. S., Stoks, J., Hazelaar, C., van Elmpt, W., Gommers, S., Volders, P. G. A., Verhoeven, K., & ter Bekke, R. M. A. (2024). 3D-targeted, electrocardiographic imaging-aided stereotactic radioablation for ventricular tachycardia storm: a case report. European Heart Journal - Case Reports, 8(10), Article ytae541. https://doi.org/10.1093/ehjcr/ytae541
- Ramos-Prada, A., Redondo-Rodríguez, A., Roca-Luque, I., Porta-Sánchez, A., Ter Bekke, R. M. A., Quintanilla, J. G., Sánchez-González, J., Peinado, R., Merino, J. L., Cluitmans, M., Holtackers, R. J., Marina-Breysse, M., Galán-Arriola, C., Enríquez-Vázquez, D., Vázquez-Calvo, S., Alfonso-Almazán, J. M., Pizarro, G., Ibáñez, B., González-Ferrer, J. J., ... Filgueiras-Rama, D. (2024). Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia. EP Europace, 26(10), Article euae244. https://doi.org/10.1093/europace/euae244
- Verheul, L. M., Hoeksema, W. F., Groeneveld, S. A., Mulder, B. A., Bootsma, M., Alings, M., Evertz, R., Blank, A. C., Kammeraad, J. A. E., Clur, S.-A. B., Yap, S.-C., Postema, P. G., Wilde, A. A. M., Volders, P. G. A., & Hassink, R. J. (2024). Comparing Adolescent- and Adult-Onset Unexplained Cardiac Arrest - Results from the Dutch Idiopathic VF registry. Heart Rhythm, 21(10), 1779-1786. https://doi.org/10.1016/j.hrthm.2024.03.031
- Serinagaoglu Dogrusoz, Y., Bear, L., Bergquist, J. A., Rababah, A., Good, W., Stoks, J., Svehlikova, J., van Dam, E., Brooks, D. H., & MacLeod, R. (2024). Evaluation of five methods for the interpolation of bad leads in the solution of the inverse electrocardiography problem. Physiological Measurement, 45(9), Article 095012. https://doi.org/10.1088/1361-6579/ad74d6
- Sabbag, A., Amoroso, G., Tomer, O., Conte, G., Beinart, R., Nof, E., Ozkartal, T., Ollitrault, P., Laredo, M., Tovia-Brodie, O., Gandjbakhch, E., de Benedictis, M., ter Bekke, R. M. A., & Milman, A. (2024). Clinical differences between drug-induced type 1 Brugada pattern and syndrome. Journal of Arrhythmia, 40(4), 982-990. https://doi.org/10.1002/joa3.13053
- Stoks, J., Patel, K. H. K., van Rees, B., Nguyen, U. C., Mihl, C., Deissler, P. M., Ter Bekke, R. M. A., Peeters, R., Vijgen, J., Dendale, P., Ng, F. S., Cluitmans, M. J. M., & Volders, P. G. A. (2024). Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging. EP Europace, 26(7), Article euae172. https://doi.org/10.1093/europace/euae172
- Verheul, L. M., Guglielmo, M., Groeneveld, S. A., Kirkels, F. P., Scrocco, C., Cramer, M. J., Bootsma, M., Kapel, G. F. L., Alings, M., Evertz, R., Mulder, B. A., Prakken, N. H. J., Balt, J. C., Volders, P. G. A., Hirsch, A., Yap, S. C., Postema, P. G., Nijveldt, R., Velthuis, B. K., ... Hassink, R. J. (2024). Mitral Annular Disjunction in Idiopathic Ventricular Fibrillation Patients: Just a Bystander or a Potential Cause?European Heart Journal Cardiovascular Imaging, 25(6), 764-770. https://doi.org/10.1093/ehjci/jeae054
- Cluitmans, M. J. M., Plank, G., & Heijman, J. (2024). Digital twins for cardiac electrophysiology: state of the art and future challenges. Herzschrittmachertherapie und Elektrophysiologie, 35(2), 118-123. https://doi.org/10.1007/s00399-024-01014-0
- Verheul, L. M., Groeneveld, S. A., Stoks, J., Hoeksema, W. F., Cluitmans, M. J. M., Postema, P. G., Wilde, A. A. M., Volders, P. G. A., & Hassink, R. J. (2024). The Dutch Idiopathic Ventricular Fibrillation Registry: progress report on the quest to identify the unidentifiable. Netherlands Heart Journal, 32(6), 238-244. https://doi.org/10.1007/s12471-024-01870-y
- Willems, E., Janssens, K. L. P. M., Dekker, L. R. C., van de Vosse, F. N., Cluitmans, M. J. M., & Bovendeerd, P. H. M. (2024). Strain-controlled electrophysiological wave propagation alters in silico scar-based substrate for ventricular tachycardia. Frontiers in physiology, 15, Article 1330157. https://doi.org/10.3389/fphys.2024.1330157
- Stevens, R. R. F., Hazelaar, C., Bogowicz, M., Ter Bekke, R. M. A., Volders, P. G. A., Verhoeven, K., de Ruysscher, D., Verhoeff, J. J. C., Fast, M. F., Mandija, S., Cvek, J., Knybel, L., Dvorak, P., Blanck, O., & van Elmpt, W. (2024). A Framework for Assessing the Effect of Cardiac and Respiratory Motion for Stereotactic Arrhythmia Radioablation Using a Digital Phantom With a 17-Segment Model: A STOPSTORM.eu Consortium Study. International Journal of Radiation Oncology Biology Physics, 118(2), 533-542. https://doi.org/10.1016/j.ijrobp.2023.08.059
- Stoks, J., Langfield, P., & Cluitmans, M. J. M. (2024). Methodological and Mechanistic Considerations in Local Repolarization Mapping. JACC: Clinical Electrophysiology, 10(2), 376-377. https://doi.org/10.1016/j.jacep.2023.12.018
- 2023
- Garcia, J. G., Arya, A., Dinov, B., Bollmann, A., ter Bekke, R. M. A., Vernooy, K., Dagres, N., Hindricks, G., & Darma, A. (2023). Impact of repeat ablation of ventricular tachycardia in patients with structural heart disease. EP Europace, 26(1), Article euad367. https://doi.org/10.1093/europace/euad367
- Verheul, L. M., van der Ree, M. H., Groeneveld, S. A., Mulder, B. A., Christiaans, I., Kapel, G. F. L., Alings, M., Bootsma, M., Barge-Schaapveld, D. Q. C. M., Balt, J. C., Yap, S.-C., Krapels, I. P. C., Ter Bekke, R. M. A., Volders, P. G. A., van der Crabben, S. N., Postema, P. G., Wilde, A. A. M., Dooijes, D., Baas, A. F., & Hassink, R. J. (2023). The genetic basis of apparently idiopathic ventricular fibrillation: a retrospective overview. EP Europace, 25(11), Article euad336. https://doi.org/10.1093/europace/euad336
- Kaya, Y. S., Stoks, J., Gommers, S., Holtackers, R. J., Duijsings, R., Vernooy, K., Volders, P., & Ter Bekke, R. (2023). Optimal pixel signal intensity threshold for the assessment of endocardial left-ventricular scar by 3D dark blood MRI compared to bipolar voltage electro-anatomical mapping. European Heart Journal, 44.
- Filgueiras-Rama, D., Ramos-Prada, A., & Cluitmans, M. J. M. (2023). Arrhythmogenic vulnerability of reentrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling. EP Europace, 25(9), Article euad258. https://doi.org/10.1093/europace/euad258
- Bergeman, A. T. J., Hoeksema, W. F. N., van der Ree, M. H., Boersma, L. V. A., Yap, S.-C., Verheul, L. M. G., Hassink, R. J., van der Crabben, S. N., Volders, P. G. A., van der Werf, C., Wilde, A. A. M. G., Postema, P. G., & European Reference Network for rare, low prevalence and complex diseases of the heart: ERN GUARD-Heart (2023). Outcomes in Dutch DPP6 risk haplotype for familial idiopathic ventricular fibrillation: a focused update. Netherlands Heart Journal, 31(7-8), 309-314. https://doi.org/10.1007/s12471-023-01792-1
- Meier, S., Grundland, A., Dobrev, D., Volders, P. G. A., & Heijman, J. (2023). In silico analysis of the dynamic regulation of cardiac electrophysiology by K(v)11.1 ion-channel trafficking. The Journal of Physiology, 601(13), 2711-2731. https://doi.org/10.1113/JP283976
- Cluitmans, M., Walton, R., & Plank, G. (2023). Editorial: Computational methods in cardiac electrophysiology. Frontiers in physiology, 14(1), Article 1231342. https://doi.org/10.3389/fphys.2023.1231342
- ter Bekke, R. M. A., de Schouwer, K., Conti, S., Claes, G. R. F., Vanoevelen, J., Gommers, S., Helderman-van den Enden, A. T. J. M., & Brunner-LaRocca, H.-P. (2023). Juvenile-onset multifocal atrial arrhythmias, atrial standstill and compound heterozygosity of genetic variants in TAF1A: sentinel event for evolving dilated cardiomyopathy-a case report. European Heart Journal - Case Reports, 7(6), Article ytad255. https://doi.org/10.1093/ehjcr/ytad255
- Rijks, J. H. J., Lankveld, T., Manusama, R., Broers, B., van Stipdonk, A. M. W., Chaldoupi, S. M., ter Bekke, R. M. A., Schotten, U., Linz, D., Luermans, J. G. L. M., & Vernooy, K. (2023). Left Bundle Branch Area Pacing and Atrioventricular Node Ablation in a Single-Procedure Approach for Elderly Patients with Symptomatic Atrial Fibrillation. Journal of Clinical Medicine, 12(12), Article 4028. https://doi.org/10.3390/jcm12124028
- Nies, H. M. J. M., Martens, B., Gommers, S., Bijvoet, G. P., Wildberger, J. E., Ter Bekke, R. M. A., Holtackers, R. J., & Mihl, C. (2023). Myocardial Scar Detection Using High-Resolution Free-Breathing 3D Dark-Blood and Standard Breath-Holding 2D Bright-Blood Late Gadolinium Enhancement MRI: A Comparison of Observer Confidence. Topics in Magnetic Resonance Imaging, 32(3), 27-32. https://doi.org/10.1097/RMR.0000000000000304
- Isaacs, A., Barysenka, A., ter Bekke, R. M. A., van den Enden, A. T. J. M. H., van den Wijngaard, A., Volders, P. G. A., & Stoll, M. (2023). Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death. Heart Rhythm, 20(5), 720-727. https://doi.org/10.1016/j.hrthm.2023.02.004
- Cluitmans, M. J. M., Bayer, J., Bear, L. R., Ter Bekke, R. M. A., Heijman, J., Coronel, R., & Volders, P. G. A. (2023). The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest. Frontiers in Cardiovascular Medicine, 10, Article 1121517. https://doi.org/10.3389/fcvm.2023.1121517
- Grehn, M., Mandija, S., Miszczyk, M., Krug, D., Tomasik, B., Stickney, K. E., Alcantara, P., Alongi, F., Anselmino, M., Aranda, R. S., Balgobind, B. V., Boda-Heggemann, J., Boldt, L. H., Bottoni, N., Cvek, J., Elicin, O., De Ferrari, G. M., Hassink, R. J., Hazelaar, C., ... Verhoeff, J. (2023). STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe. EP Europace, 25(4), 1284-1295. https://doi.org/10.1093/europace/euac238
- Leao, S., Luermans, J., Vernooy, K., ter Bekke, R., den Uijl, D., Linz, D., & Chaldoupi, S.-M. (2023). The great deceiver: a case series of 'double fire' atrioventricular nodal response. European Heart Journal - Case Reports, 7(4), Article ytad162. https://doi.org/10.1093/ehjcr/ytad162




