PI group Leon Schurgers
- 2026
- Potjewijd, J., Tobal, R., van Doorn, D. P. C., Schurgers, L. J., Heeringa, P., Damoiseaux, J. G. M. C., & van Paassen, P. (2026). Soluble immune checkpoints reflect immune activation and treatment response in high-risk systemic sclerosis patients treated with plasma exchange. Journal of Translational Autoimmunity, 12, Article 100361. https://doi.org/10.1016/j.jtauto.2026.100361
- Goossens, S. H., van der Reijden, J. J., Tseng, C. M. E. S. N., Hoogeveen, A. R., Vaes, R., Jan de Borst, G., Schurink, G. W., & Scheltinga, M. R. M. (2026). Short-term analysis of botulinum toxin A for functional popliteal artery entrapment syndrome. Journal of Vascular Surgery Cases and Innovative Techniques, 12(2), Article 102139. https://doi.org/10.1016/j.jvscit.2026.102139
- Frankort, J., Keszei, A., Doukas, P., Uhl, C., Jacobs, M. J., Mees, B. M. E., Gombert, A., & Elfeky, M. (2026). Outcome following open TAAA repair after TEVAR compared to conventional open type II TAAA repair. Vasa-European Journal of Vascular Medicine, 55(2 Special Issue:Complex aortic pathologies), 114-120. https://doi.org/10.1024/0301-1526/a001247
- You, W., Berendschot, T. T. J. M., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2026). Potential and value of rescuing dying neurons. Neural Regeneration Research, 21(3), 1013-1022. https://doi.org/10.4103/NRR.NRR-D-24-01134
- Lima, L. S., Ribeiro, M., Cardozo, L. F. M. F., Bittner, R., Ribeiro-Alves, M., Schultz, J., Rosado, A. S., Leite, P. E. C., Nakao, L. S., Schurgers, L. J., & Mafra, D. (2026). Association of poor vitamin K status with inflammation and gut microbiota in hemodialysis patients: A cross-sectional study. Journal of Nutritional Biochemistry, 148, Article 110139. https://doi.org/10.1016/j.jnutbio.2025.110139
- Wanhainen, A., Gombert, A., Antoniou, G. A., Domingos, L. A. F., Gouveia e Melo, R., Grabenwoger, M., Haulon, S., Katsargyris, A., Kolbel, T., Loftus, I. M., Mani, K., Mees, B. M. E., Melissano, G., Pedro, L. M., Prendes, C. F., Spanos, K., Tsilimparis, N., Van Herzeele, I., Venermo, M., ... Vermassen, F. E. G. (2026). European Society for Vascular Surgery (ESVS) 2026 Clinical Practice Guidelines on the Management of Descending Thoracic and Thoraco-Abdominal Aortic Diseases – Editor's Choice. European Journal of Vascular and Endovascular Surgery, 71(2), 172-270. https://doi.org/10.1016/j.ejvs.2025.12.050
- Greenleaf, E. K., Maximus, S., Oden-Brunson, H., Ferreira, Z. C., Miranda, J., Huang, Y., Mees, B., & Oderich, G. S. (2026). Historical Evolution of Physician-Modified Endografts (PMEGs) for Treatment of Complex Aortic Aneurysms. Annals of Vascular Surgery, 123, 636-652. https://doi.org/10.1016/j.avsg.2025.10.015
- Barb, A., Uhl, C., Bornhak, L., El-Sanosy, E., Fink, M., Böckler, D., Hatzl, J., Zephyr study group collaborators, & Mees, B. (2026). Accuracy of fully automated iliac artery tortuosity measurements in patients with abdominal aortic aneurysm using deep learning. European Journal of Radiology, 195, Article 112609. https://doi.org/10.1016/j.ejrad.2025.112609
- Stenvinkel, P., Kotanko, P., Painer-Gigler, J., Shiels, P. G., Evenepoel, P., Schurgers, L., Natterson-Horowitz, B., Kalogeropoulu, S., Schiffman, J., & Johnson, R. J. (2026). Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?Diabetologia, 69(2), 295-307. https://doi.org/10.1007/s00125-025-06611-3
- Doukas, P., Bassett, C., Hruschka, B., Kuzmanova, E., Wessels, I., Klump, H. J., Schurgers, L. J., Jacobs, M. J., Uhl, C., Gombert, A., & Huang, J. T. J. (2026). Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity. International Journal of Molecular Sciences, 27(3), Article 1236. https://doi.org/10.3390/ijms27031236
- Schanzer, A., Schneider, D. B., Timaran, C., Beck, A. W., Schermerhorn, M., Schurink, G. W., van Herwaarden, J., Modarai, B., Moreels, N., Cochennec, F., Resch, T., & Kölbel, T. (2026). Design of the RadFree randomized controlled study comparing LumiGuide, powered by Fiber Optic RealShape Technology, with conventional fluoroscopy guidance in fenestrated endovascular aortic repair. Jvs Vascular Insights, 4, Article 100354. https://doi.org/10.1016/j.jvsvi.2026.100354
- Vleugels, M.-J., Moser, A., van den Beuken-van Everdingen, M., Mees, B., & Hendriks, J. M. (2026). Nurses in the lead: advancement of integrated palliative care and professional autonomy in peripheral arterial disease. European Journal of Cardiovascular Nursing. Advance online publication. https://doi.org/10.1093/eurjcn/zvag005
- Karelis, A., Adam, D., Piazza, M., Tinelli, G., Gallito, E., Matsagkas, M., Mees, B., Mani, K., D'Oria, M., Mansour, W., Cieri, E., Kolbel, T., Sonesson, B., Dias, N., & PEACE, C. (2026). Parallel Endografting And Chimney Endovascular (PEACE) registry outcomes in emergency repair of complex abdominal aortic aneurysms. British Journal of Surgery, 113(1), Article znaf278. https://doi.org/10.1093/bjs/znaf278
- van der Wilt, C. N., Veltrop, R. J. A., Janssens, M. H., Bakker, I., Stillitano, F., Sluijter, J. P. G., van Laake, L. W., van der Velden, J., Villard, E., Montag, J., Denning, C., van Tintelen, J. P., Te Riele, A. S. J. M., van der Harst, P., Schurgers, L. J., van Steenbeek, F. G., & Harakalova, M. (2026). Setting the stage for cardiomyopathy gene editing trials: a systematic review of isogenic pair use in human induced pluripotent stem cell-derived cardiomyocyte research. European heart journal open, 6(1), Article oeaf161. https://doi.org/10.1093/ehjopen/oeaf161
- 2025
- Meulendijks, E. R., Fabrizi, B., Bruns, S., Eringa, E. C., Hoebe, R., van den Boogert, T., Wesselink, R., Al-Shama, R. F. M., de Vries, T. A. C., Ernault, A. C., Niessen, H. W. M., van Boven, W. J. P., Driessen, A. H. G., Zbairi, I., Zappala, P., Dey, D., Isgum, I., Planken, R. N., Krul, S. P. J., & de Groot, J. R. (2025). Patients with persistent atrial fibrillation and metabolic comorbidities have an altered inflammatory state of atrial epicardial adipose tissue, which is linked to CT-attenuation. Cardiovascular Diabetology, 25(1), Article 82. https://doi.org/10.1186/s12933-025-02985-1
- Kopytina, V., Marchant, V., Rodrigues-Diez, R., Pascual-Anton, L., Toggweiler, N., Strahl, L., Kane, J., Tejera-Munoz, A., Cortes, M., Sucunza, D., Vaquero, J. J., Vervloet, M., Piecha, D., Eringa, E. C., Ruiz-Ortega, M., Lopez-Cabrera, M., & Gonzalez-Mateo, G. T. (2025). Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions. Nephrology Dialysis Transplantation, Article gfaf249. https://doi.org/10.1093/ndt/gfaf249
- Lanzer, P., Schurgers, L., Twarda-Clapa, A., Ferraresi, R., Hui, H., Kamenskiy, A., Chen, Y., Hamana, T., Fok, P.-W., Millán, Á., Virmani, R., & St Hilaire, C. (2025). Medial arterial calcification in ageing and disease: current evidence and knowledge gaps. European Heart Journal, 46(45), 4876-4900. https://doi.org/10.1093/eurheartj/ehaf341
- Al-Chalabi, S., Sinha, S., Kalra, P. A., Evans, D., Green, D., Schurgers, L., & Poulikakos, D. (2025). A Randomised Prospective Crossover Study on the Effects of Medium Cut-Off Membranes on FGF-23 and Inflammatory Mediators in Patients Receiving Regular Haemodialysis. Blood Purification, 54(11), 639-651. https://doi.org/10.1159/000545745
- Ramos, K. S., Nassiri, S., Wijdeveld, L. F. J., van der Palen, R. L., Kuipers, M. F., Hills, M. T., Slijkerman, P., van Raalte, D. H., Handoko, M. L., de Groot, N. M. S., Grewal, N., Klautz, R. J. M., Eringa, E. C., & Brundel, B. J. J. M. (2025). Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY). Cardiovascular Drugs and Therapy, 39(6), 1589-1595. https://doi.org/10.1007/s10557-025-07693-2
- Niederau, C., Maas, S. L., van der Vorst, E. P. C., Schurgers, L. J., Shi, Y., Holzle, F., Wolf, M., & Craveiro, R. B. (2025). Jaw-specific differential kinase activity profiles in human periodontal ligament stem cells under mechanical compression. Stem Cell Research & Therapy, 16(1), Article 624. https://doi.org/10.1186/s13287-025-04778-5
- Frankort, J., Frankort, S., Doukas, P., Uhl, C., Elfeky, M., Mees, B. M. E., Gombert, A., & Jacobs, M. J. (2025). Shift in Patient Demographics of Open Thoracoabdominal Aortic Aneurysm Repair Patients in the Endovascular Era. Journal of Clinical Medicine, 14(19), Article 7088. https://doi.org/10.3390/jcm14197088
- Jin, H., Maas, S. L., Zou, Y., Lu, C., Yu, B., Huchzermeier, R., Nadeau, S., Dos Santos, J., Gijbels, M., Mees, B. M. E., Smirnov, E., Matic, L., Hedin, U., Maffia, P., Monaco, C., Sluimer, J. C., Martins, G. A., van der Vorst, E. P. C., & Biessen, E. A. L. (2025). Identification of a PRDM1-regulated T cell network to regulate atherosclerotic plaque inflammation. Genome Medicine, 17(1), Article 109. https://doi.org/10.1186/s13073-025-01541-6
- Kalaja, I., Smeets, R. R., Wegner, M., Macherey-Meyer, S., Heyne, S., Espinola-Klein, C., Mees, B. M. E., & Meertens, M. M. (2025). Ultrasound Guided Versus Conventional Closure Device Deployment Following Transfemoral Endovascular Procedures: A Systematic Review and Meta-analysis. European Journal of Vascular and Endovascular Surgery, 70(4), 469-479. https://doi.org/10.1016/j.ejvs.2025.06.023
- Miranda, M., Leoni, M., van der Zwaan, C., van Bruggen, R., Reutelingsperger, C. P. M., Fijnvandraat, K., Hoogendijk, A. J., van den Biggelaar, M., Voorberg, J., & Collaborative group: EDUC8 consortium (2025). MHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells. Frontiers in Immunology, 16, Article 1668397. https://doi.org/10.3389/fimmu.2025.1668397
- van Mourik, N., van Amstel, R. B. E., Slim, M. A., van Vught, L. A., van der Poll, T., Huckriede, J., de Vries, F., de Kimpe, S. J., Crabbe, R., van Leeuwen, S. J. M., Ekhart, P. F., Reutelingsperger, C. P. M., Nicolaes, G. A. F., Vlaar, A. P. J., & Mueller, M. C. A. (2025). A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients. Intensive Care Medicine Experimental, 13(1), Article 84. https://doi.org/10.1186/s40635-025-00790-4
- Heuschkel, M. A., Jaminon, A., Gräber, S., Artati, A., Adamski, J., Jankowski, J., Schurgers, L., Marx, N., Jahnen-Dechent, W., & Goettsch, C. (2025). Hypotaurine Reduces Glucose-Mediated Vascular Calcification. Acta Physiologica, 241(8), Article e70075. https://doi.org/10.1111/apha.70075
- Durakiewicz, M., Konings, T. J. A. J., & Mees, B. M. E. (2025). Covered Endovascular Reconstruction of The Coeliac Artery Bifurcation to Treat Hepatic Artery Aneurysm. European Journal of Vascular and Endovascular Surgery, 70(2), 276. https://doi.org/10.1016/j.ejvs.2025.04.021
- Huckriede, J., Keulen, G. M., van de Poll, M. C. G., Wichapong, K., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2025). Proteolytic neutralization of extracellular histones by neutrophil elastase is enhanced by heparin. Journal of Thrombosis and Haemostasis, 23(8), 2483-2493. https://doi.org/10.1016/j.jtha.2025.03.039
- Nassiri, S., Voordes, G. H. D., van Heerebeek, L., van Raalte, D. H., Verhaar, M. C., Touw, D. J., Krebber, M. M., Duncker, D. J., Eringa, E. C., Handoko, M. L., Voors, A. A., & RECONNEXT Consortium (2025). Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo-controlled, crossover trial. European journal of heart failure. Advance online publication. https://doi.org/10.1002/ejhf.3711
- Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
- Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
- Vacirca, A., Mesnard, T., Huang, Y., Mendes, B. C., Jakimowicz, T., Schneider, D. B., Haulon, S., Sobocinski, J., Beck, A. W., Schanzer, A., Farber, M. A., Timaran, C., Kahlberg, A., Kölbel, T., Gasper, W. J., Mees, B. M. E., Gargiulo, M., Dias, N. V., Woongchae, A. L., ... International Multicenter Aortic Research Group (2025). Predictors of failure to rescue after fenestrated-branched endovascular aortic repair of thoracoabdominal aortic aneurysms. Journal of Vascular Surgery, 82(1), 32-42.e3. https://doi.org/10.1016/j.jvs.2025.02.032
- Purvis, G. S. D., Chiazza, F., Chen, J., Azevedo-Loiola, R., Martin, L., Kusters, D. H. M., Reutelingsperger, C., Fountoulakis, N., Gnudi, L., Yaqoob, M. M., Collino, M., Thiemermann, C., & Solito, E. (2025). Retraction Note: Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia, 68(7), 1589. https://doi.org/10.1007/s00125-025-06418-2
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Correction: Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1637511. https://doi.org/10.3389/fimmu.2025.1637511
- Saar-Kovrov, V., Pawlowska, A., Guillot, A., Gijbels, M. J. J., Sluimer, J. C., Temmerman, L., Goossens, P., Mees, B. M. E., Tacke, F., Jankowski, V., Jankowski, J., Donners, M. M. P. C., & Biessen, E. A. L. (2025). Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells. Frontiers in Immunology, 16, Article 1532250. https://doi.org/10.3389/fimmu.2025.1532250
- Janssen-Telders, C., Eringa, E. C., de Groot, J. R., de Man, F. S., & Handoko, M. L. (2025). The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction. Cardiovascular Research, 121(6), 860-870. https://doi.org/10.1093/cvr/cvaf056
- Suthahar, N., Mourmans, S. G. J., Achten, A., Aboumsallem, J. P., Meijers, W. C., Bomer, N., Kardys, I., Gansevoort, R. T., Bakker, S. J. L., Weerts, J., Eringa, E. C., Damman, K., van Empel, V., & de Boer, R. A. (2025). Peroxiredoxin-4, a marker of systemic oxidative stress, is associated with incident heart failure. European journal of heart failure, 27(5), 905-911. Article 3653. https://doi.org/10.1002/ejhf.3653
- Saraber, P., Bica, L., Reesink, K., Mees, B., Bidar, E., Schurger, L., & Heuts, S. (2025). The clinical relevance of the decelerating effect of angiotensin receptor blockers on aortic growth in Marfan patients; a Bayesian perspective. International Journal of Cardiology, 433, Article 133318. https://doi.org/10.1016/j.ijcard.2025.133318
- Mourmans, S. G. J., Achten, A., Hermans, R., Scheepers, M. J. E., D'Alessandro, E., Swennen, G., Woudstra, J., Appelman, Y., Goor, H. V., Schalkwijk, C., Knackstedt, C., Weerts, J., Eringa, E. C., & van Empel, V. P. M. (2025). The effect of empagliflozin on peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction. Cardiovascular Diabetology, 24(1), Article 182. https://doi.org/10.1186/s12933-025-02679-8
- Frankort, J., Frankort, S., Doukas, P., Uhl, C., Jacobs, M. J., Mees, B. M. E., & Gombert, A. (2025). Outcome Following Open Repair of Hereditary and Non-Hereditary Thoracoabdominal Aortic Aneurysm in Patients Under 60 Years Old-A Multicenter Study. Journal of Clinical Medicine, 14(7), Article 2513. https://doi.org/10.3390/jcm14072513
- Katsargyris, A., Haulon, S., Verhoeven, E. L. G., Early Launch Collaborators, & Mees, B. (2025). Editor's Choice – Initial Experience with the BeFlared Bridging Covered Stent for Fenestrated Endovascular Aneurysm Repair. European Journal of Vascular and Endovascular Surgery, 69(4), 651-652. https://doi.org/10.1016/j.ejvs.2025.01.029
- Vleugels, M.-J., Gilissen, M., van de Water, W., Moser, A., van den Beuken-van Everdingen, M., & Mees, B. (2025). Potentially Inappropriate Care in Patients with Chronic Limb Threatening Ischaemia in the Last Month of Life. European Journal of Vascular and Endovascular Surgery, 69(4), 653-654. https://doi.org/10.1016/j.ejvs.2024.12.022
- Wegner, M., Smeets, R. R., Veenstra, L. F., Ahmad, W., Behrens, A. L., Kursch, F., Wienemann, H., Dorweiler, B., Baldus, S., Adam, M., Mees, B. M. E., & Meertens, M. M. (2025). Comparison of patients with occlusive or hemorrhagic access site complications requiring reintervention after percutaneous transfemoral transcatheter aortic valve implantation. Vasa-European Journal of Vascular Medicine, 54(2), 133-141. https://doi.org/10.1024/0301-1526/a001154
- de la Puente-secades, S., Mikolajetz, D., Gayrard, N., Hermann, J., Jankowski, V., Bhargava, S., Meyer, A., Argiles, A., Saritas, T., van der Vorst, E. P. C., Wu, Z., Noels, H., Tepel, M., Alghamdi, K., Ward, D., Zidek, W., Wolf, M., Floege, J., Schurgers, L., ... Jankowski, J. (2025). Vasoconstriction-inhibiting factor: an endogenous inhibitor of vascular calcification as a calcimimetic of calcium-sensing receptor. Cardiovascular Research, 121(3), 507-521. https://doi.org/10.1093/cvr/cvaf016
- Bassett, C., Doukas, P., Gombert, A., Schurgers, L., Jacobs, M., Uhl, C., & Hruschka, B. (2025). Degradation elastischer Fasern in thorakoabdominellen Aortenaneurysmen: Ein multinationales und multizentrisches Forschungsprojekt mit Vorbildcharakter. Gefässchirurgie, 30(2), 79-82. https://doi.org/10.1007/s00772-025-01181-5
- de Vries, F., Bittner, R., Maresz, K., Machuron, F., Gåserød, O., Jeanne, J.-F., & Schurgers, L. J. (2025). Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women. Nutrients, 17(5), Article 815. https://doi.org/10.3390/nu17050815
- Negm, S., Wolf, M., Craveiro, R. B., Schurgers, L., Jankowski, J., Schneider, R. K., Rizk, M., Coenen, F., Knaup, I., Brenji, S., & Niederau, C. (2025). Resveratrol modulates phosphorylation of ERK and AKT in murine cementoblasts during in vitro orthodontic compression. BMC Oral Health, 25(1), Article 226. https://doi.org/10.1186/s12903-025-05591-5
- Wahlgren, C. M., Aylwin, C., Davenport, R. A., Davidovic, L. B., Dubose, J. J., Gaarder, C., Heim, C., Jongkind, V., Jorgensen, J., Kakkos, S. K., Mcgreevy, D. T., Ruffino, M. A., de Ceniga, M. V., Vikatmaa, P., Ricco, J.-B., Brohi, K., Antoniou, G. A., Boyle, J. R., Coscas, R., ... ESVS Guidelines Committee (2025). Editor's Choice - European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Guidelines on the Management of Vascular Trauma. European Journal of Vascular and Endovascular Surgery, 69(2), 179-237. https://doi.org/10.1016/j.ejvs.2024.12.018
- Atash, A., Cramer, M. J., Mees, B., Doevendans, P. A., Sluijter, J. P. G., & Stillitano, F. (2025). Generation and characterization of novel induced pluripotent stem cell (iPSC) lines derived from three symptomatic carriers of a pathogenic MYH11 variant and two non-carrier relatives. Stem Cell Research, 82, Article 103630. https://doi.org/10.1016/j.scr.2024.103630



