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Social and economic background influences survival in intensive care: Research with societal impact

Social and economic background influences survival in intensive care: Research with societal impact

18 August 2026

A large-scale study by researchers from Maastricht UMC+ and Amsterdam UMC demonstrates that lower socioeconomic status (SES) of patients admitted to Dutch intensive care units contributes to worse survival.

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Fatma Karapinar appointed as Professor in Medication Safety

Fatma Karapinar appointed as Professor in Medication Safety

12 August 2026

As of 1 June 2026, Dr Fatma Karapinar has been appointed Professor of Medication Safety at Maastricht University.

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Carim Maastricht
Carim Maastricht

Publications

Section Fatma Karapinar Section Martijn Brouwers
  • 2005
    • de Jager, J., Kooy, A., Lehert, P., Bets, D., Wulffele, M. G., Teerlink, T., Scheffer, P. G., Schalkwijk, C. G., Donker, A. J., & Stehouwer, C. D. (2005). Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial. Journal of Internal Medicine, 257(1), 100-109. https://doi.org/10.1111/j.1365-2796.2004.01420.x
    • Hemelaar, M., van der Mooren, M. J., van Baal, W. M., Schalkwijk, C. G., Kenemans, P., & Stehouwer, C. D. A. (2005). Effects of transdermal and oral postmenopausal hormone therapy on vascular function a randomized placebo-controlled study in healthy postmenopausal women. Menopause-The Journal of the North American Menopause Society, 12, 526-535. https://doi.org/10.1097/01.GME.0000153888.94399.AF
    • Konings, C. J. A. M., Schalkwijk, C. G., van der Sande, F. M., Leunissen, K. M. L., & Kooman, J. P. (2005). Influence of icodextrin on plasma and dialysate levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine. Peritoneal Dialysis International, 25(6), 591-595. https://doi.org/10.1177/089686080502500616
    • Schram, M. T., Chaturvedi, N., Schalkwijk, C. G., Fuller, J. H., Stehouwer, C. D. A., & EURODIAB ProspectivE Compl.St., G. (2005). Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes--the EURODIAB Prospective Complications Study. Diabetologia, 48(2), 370-378. https://doi.org/10.1007/s00125-004-1628-8
    • Nanayakkara, P. W. B., Teerlink, T., Stehouwer, C. D. A., Allajar, D., Spijkerman, A. M. W., Schalkwijk, C. G., ter Wee, P. M., & van Guldener, C. (2005). Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure. Kidney International, 68, 2230-2236. https://doi.org/10.1111/j.1523-1755.2005.00680.x
    • Wouters, K. A. M., Shiri-Sverdlov, R., van Gorp, P. J. J., van Bilsen, M., & Hofker, M. H. (2005). Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice. Clinical Chemistry and Laboratory Medicine, 43(5), 470-479. https://doi.org/10.1515/CCLM.2005.085
    • Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F., & de Bruin, T. W. (2005). Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia. Faseb Journal, 19(14), 2063-2065. https://doi.org/10.1096/fj.04-2403fje
    • Schalkwijk, C. G., & Stehouwer, C. D. (2005). Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clinical Science, 109(2), 143-159. https://doi.org/10.1042/CS20050025
  • 2004
    • van Onna, M. J. H., Kroon, A. A., Houben, A. J. H. M., Koster, D., Zeegers, M. P. A., Henskens, L. H. G., Plat, A. W., Stoffers, H. E. J. H., & de Leeuw, P. W. (2004). Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renal angiography cohort. Hypertension, 44(4), 448-453. https://doi.org/10.1161/01.HYP.0000141440.02210.da
    • van de Kerkhof, J., Schalkwijk, C. G., Konings, C. J. A. M., Cheriex, E. C., van der Sande, F. M., Scheffer, P. G., ter Wee, P. M., Leunissen, K. M. L., & Kooman, J. P. (2004). Nepsilon-(carboxymethyl)lysine, Nepsilon-(carboxyethyl)lysine and vascular cell adhesion molecule-1 (VCAM-1) in relation to peritoneal glucose prescription and residual renal function; a study in peritoneal dialysis patients. Nephrology Dialysis Transplantation, 19(4), 910-916. https://doi.org/10.1093/ndt/gfh004
  • 2003
    • Henskens, L. H. G., Spiering, W., Stoffers, H. E. J. H., Soomers, F. L. M., Vlietinck, R. F. M., de Leeuw, P. W., & Kroon, A. A. (2003). Effects of ACE I/D and AT1R-A1166C polymorphisms on blood pressure in a healthy normotensive primary care population: first results of the Hippocates study. Journal of Hypertension, 21(1), 81-86. https://doi.org/10.1097/00004872-200301000-00017
    • Rodriguez-Hernandez, S., Kroon, A. A., van Boxtel, M. P. J., Mess, W. H., Lodder, J., Jolles, J., & de Leeuw, P. W. (2003). Is there a side predilection for cerebrovascular disease?Hypertension, 42, 56-60. https://doi.org/10.1161/01.HYP.0000077983.66161.6F
    • Abou el Hassan, M. A., Verheul, H. M., Jorna, A. S., Schalkwijk, C. G., van Bezu, J., van der Vijgh, W. J. F., & Bast, A. (2003). The new cardioprotector Monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro. British Journal of Cancer, 89(2), 357-362. https://doi.org/10.1038/sj.bjc.6601022
    • Eurlings, P. M. H., van der Kallen, C. J. H., Vermeulen, V. M. M. J., & de Bruin, T. W. A. (2003). Variants in the PPARgamma gene affect fatty acid and glycerol metabolism in familial combined hyperlipidemia. Molecular Genetics and Metabolism, 80(3), 296-301. https://doi.org/10.1016/S1096-7192(03)00138-0
  • 2002
    • Rodriguez-Hernandez, S., van Boxtel, M. P. J., Kroon, A. A., Mess, W. H., Lodder, J., & Jolles, J. (2002). Carotid intima media thickness asymetry in an untreated uncomplicated hypertensive population.Cerebrovascular Diseases, 13(suppl 4, 1-53.
    • van Greevenbroek, M. M. J., Vermeulen, V. M. M. J., & de Bruin, T. W. A. (2002). Familial combined hyperlipidemia plasma stimulates protein secretion by HepG2 cells: identification of fibronectin in the differential secretion proteome. Journal of Lipid Research, 43(11), 1846-1854. https://doi.org/10.1194/jlr.M100441-JLR200
    • Keulen, E. T. P., Wyse, D. G., Houben, A. J. H. M., van Lin, J. M., Lutgens, L. C. H. W., Rijkers, K., Dallinga-Thie, G. M., & de Bruin, T. W. A. (2002). Reduced structural and functional skin capillaries in familial combined hyperlipidemia affected men, associated with increased remnant-like lipoprotein cholesterol levels. Atherosclerosis, 163(2), 355-362. https://doi.org/10.1016/S0021-9150(02)00021-7
  • 2000
    • van Greevenbroek, M. M. J., van der Kallen, C. J. H., & de Bruin, T. W. A. (2000). Caco-2 cells secrete two independent classes of lipoproteins with distinct density: effect of the ratio of unsaturated to saturated fatty acid. Atherosclerosis, 149(1), 25-31. https://doi.org/10.1016/S0021-9150(99)00289-0
    • van der Kallen, C. J. H., Cantor, R. M., van Greevenbroek, M. M. J., Geurts, J. M. W., Bouwman, F. G., Aouizerat, B. E., Allayee, H., Buurman, W. A., Lusis, A. J., Rotter, J. L., & de Bruin, T. W. A. (2000). Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. International Journal of Obesity, 24(11), 1381-1391. https://doi.org/10.1038/sj.ijo.0801412
    • Geurts, J. M. W., Janssen, R. G. J. H., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Cantor, R. M., Bu, X., Aouizerat, B. E., Allayee, H., Lanning, C. D., Buurman, W. A., Rotter, J. L., & de Bruin, T. W. A. (2000). Identification of TNFRSF-1B as a novel modifier gene in familial combined hyperlipidemia. Human Molecular Genetics, 9(14), 2067-2074. https://doi.org/10.1093/hmg/9.14.2067
    • van Greevenbroek, M. M. J., van der Kallen, C. J. H., Geurts, J. M. W., Janssen, R. G. J. H., Buurman, W. A., & de Bruin, T. W. A. (2000). Soluble receptors for tumor necrosis factor alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia. Atherosclerosis, 153(1), 1-8. https://doi.org/10.1016/S0021-9150(00)00375-0
  • 1999
    • Huvers, F. C., de Leeuw, P. W., Houben, A. J. H. M., de Haan, C. H. A., Hamulyak, K., Schouten, H. J. A., Wolffenbuttel, B. H. R., Wyse, D. G., & Schaper , NC. (1999). Endothelium-dependent vasodilatation, plasma markers of endothelial function, and adrenergic vasoconstrictor responses in type 1 diabetes under near-normoglycemic conditions.Diabetes, 48(6), 1300-1307. https://doi.org/10.2337/diabetes.48.6.1300
  • 1998
    • van Greevenbroek, M. M. J., & de Bruin, T. W. A. (1998). Chylomicron synthesis by intestinal cells in vitro and in vivo.Atherosclerosis, 141(Suppl.), S9-S16. https://doi.org/10.1016/S0021-9150(98)00212-3
    • van Greevenbroek, M. M. J., Robertus-Teunissen, M. G., Erkelens, D. W., & de Bruin, T. W. A. (1998). Lipoprotein secretion by intestinal Caco-2 cells is affected differently by trans and cis unsaturated fatty acids: effect of carbon chain length and position of the double bond.American Journal of Clinical Nutrition, 68(3), 561-567. https://doi.org/10.1093/ajcn/68.3.561
    • van Greevenbroek, M. M. J., Robertus-Teunissen, M. G., Erkelens, D. W., & de Bruin, T. W. A. (1998). Participation of the microsomal triglyceride transfer protein in lipoprotein assembly in Caco-2 cells: interaction with saturated and unsaturated dietary fatty acids.Journal of Lipid Research, 39(1), 173-185. https://doi.org/10.1016/S0022-2275(20)34213-9